Description

Follow-up analyses of GWIS findings

  • Table of significant and suggestive (1df GxE only) active_met_875 GWIS findings
  • GxE models stratified by study_design and tumor site (proximal, distal, rectal)
  • GxE models with additional covariate sets (might do this for aspirin ..)
  • Odds ratios stratified by exposure and genotype
  • Plots of model predicted outcome by 1 unit increase of exposure/allelic dosage
  • Locuszoom plot
  • Functional annotation plot

Two-step findings

chr15_33001734_T_A

Allele freq

GxE model by sex

sex stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Female (Ca=8677,Co=12005) Male (Ca=7706,Co=11604)
(1) (2) (3)
chr15_33001734_T_A_dose 1.038 (0.961, 1.115) 1.074 (0.978, 1.170) 0.979 (0.849, 1.110)
active_met_875Yes 0.802*** (0.739, 0.866) 0.836*** (0.754, 0.918) 0.762*** (0.661, 0.863)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 1.000 (0.996, 1.003)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.028 (0.977, 1.079)
chr15_33001734_T_A_dose:active_met_875Yes 1.170*** (1.081, 1.259) 1.123* (1.008, 1.238) 1.248** (1.103, 1.392)
Constant 0.587** (0.231, 0.942) 0.530* (0.020, 1.040) 0.707 (0.202, 1.212)
Observations 39,992 20,682 19,310
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 5.594e-04
LRtest p = 4.803e-02
LRtest p = 2.654e-03

GxE model by study design

study_design stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Cohort (Ca=10301,Co=18860) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_33001734_T_A_dose 1.038 (0.961, 1.115) 1.043 (0.958, 1.129) 1.006 (0.820, 1.192)
active_met_8751 0.802*** (0.739, 0.866) 0.837*** (0.766, 0.908) 0.675*** (0.528, 0.822)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.022 (0.957, 1.088) 1.014 (0.933, 1.094)
chr15_33001734_T_A_dose:active_met_8751 1.170*** (1.081, 1.259) 1.147** (1.046, 1.248) 1.239* (1.038, 1.440)
Constant 0.587** (0.231, 0.942) 1.008 (0.686, 1.330) 0.425*** (-0.032, 0.882)
Observations 39,992 29,161 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 5.594e-04
LRtest p = 7.858e-03
LRtest p = 3.746e-02

GxE model by tumor site

cancer_site_sum2 stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Proximal (Ca=4370,Co=23609) Distal (Ca=5625,Co=23609) Rectal (Ca=4480,Co=23609)
(1) (2) (3) (4)
chr15_33001734_T_A_dose 1.038 (0.961, 1.115) 0.978 (0.853, 1.103) 1.040 (0.931, 1.148) 1.073 (0.930, 1.215)
active_met_8751 0.802*** (0.739, 0.866) 0.727*** (0.625, 0.829) 0.782*** (0.691, 0.874) 0.873* (0.758, 0.989)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.048 (0.970, 1.126) 0.803*** (0.728, 0.877) 1.337*** (1.260, 1.415)
chr15_33001734_T_A_dose:active_met_8751 1.170*** (1.081, 1.259) 1.176* (1.032, 1.319) 1.200** (1.074, 1.327) 1.180* (1.022, 1.338)
Constant 0.587** (0.231, 0.942) 0.252*** (-0.307, 0.810) 0.073*** (-0.431, 0.577) 0.393*** (-0.158, 0.943)
Observations 39,992 27,979 29,234 28,089
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 5.594e-04
LRtest p = 2.621e-02
LRtest p = 4.450e-03
LRtest p = 3.824e-02

GxE model by bmi

bmic3 stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Normal (Ca=5528,Co=8430) Overweight (Ca=3672,Co=4735) Obese (Ca=6902,Co=10154)
(1) (2) (3) (4)
chr15_33001734_T_A_dose 1.038 (0.961, 1.115) 1.081 (0.937, 1.225) 0.989 (0.843, 1.135) 1.024 (0.902, 1.145)
active_met_8751 0.802*** (0.739, 0.866) 0.804*** (0.691, 0.918) 0.790*** (0.660, 0.921) 0.856** (0.756, 0.956)
age_ref_imp 1.003* (1.000, 1.006) 1.004 (1.000, 1.008) 1.004 (0.997, 1.010) 1.000 (0.996, 1.004)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 0.965 (0.877, 1.053) 1.169** (1.054, 1.284) 0.976 (0.897, 1.055)
chr15_33001734_T_A_dose:active_met_8751 1.170*** (1.081, 1.259) 1.162 (1.001, 1.323) 1.310** (1.130, 1.490) 1.135 (0.995, 1.274)
Constant 0.587** (0.231, 0.942) 0.419** (-0.143, 0.982) 1.492 (0.519, 2.465) 0.600 (-0.023, 1.222)
Observations 39,992 13,958 8,407 17,056
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 5.594e-04
LRtest p = 6.788e-02
LRtest p = 3.235e-03
LRtest p = 7.550e-02

GxE model by sex (CRC)

sex stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Female (Ca=7898,Co=11164) Male (Ca=7131,Co=10765)
(1) (2) (3)
chr15_33001734_T_A_dose 1.050 (0.968, 1.132) 1.080 (0.978, 1.182) 1.001 (0.863, 1.139)
active_met_8751 0.803*** (0.736, 0.870) 0.836*** (0.748, 0.923) 0.768*** (0.661, 0.875)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 0.999 (0.996, 1.003)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000** (1.000, 1.000)
sex 1.025 (0.973, 1.076)
chr15_33001734_T_A_dose:active_met_8751 1.161** (1.067, 1.255) 1.120 (0.999, 1.241) 1.225** (1.073, 1.377)
Constant 0.569** (0.208, 0.930) 0.522* (0.005, 1.039) 0.667 (0.152, 1.182)
Observations 36,958 19,062 17,896
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.824e-03
LRtest p = 6.687e-02
LRtest p = 8.851e-03

GxE model by study design (CRC)

study_design stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Cohort (Ca=8947,Co=17180) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_33001734_T_A_dose 1.050 (0.968, 1.132) 1.059 (0.967, 1.151) 1.006 (0.820, 1.192)
active_met_8751 0.803*** (0.736, 0.870) 0.843*** (0.767, 0.920) 0.675*** (0.528, 0.822)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.020 (0.953, 1.087) 1.014 (0.933, 1.094)
chr15_33001734_T_A_dose:active_met_8751 1.161** (1.067, 1.255) 1.134* (1.026, 1.242) 1.239* (1.038, 1.440)
Constant 0.569** (0.208, 0.930) 0.993 (0.652, 1.335) 0.425*** (-0.032, 0.882)
Observations 36,958 26,127 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.824e-03
LRtest p = 2.255e-02
LRtest p = 3.746e-02

GxE model by tumor site (CRC)

cancer_site_sum2 stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Proximal (Ca=4367,Co=21929) Distal (Ca=5625,Co=21929) Rectal (Ca=4404,Co=21929)
(1) (2) (3) (4)
chr15_33001734_T_A_dose 1.050 (0.968, 1.132) 0.986 (0.861, 1.111) 1.048 (0.939, 1.157) 1.087 (0.942, 1.232)
active_met_8751 0.803*** (0.736, 0.870) 0.730*** (0.628, 0.832) 0.787*** (0.695, 0.879) 0.884* (0.767, 1.001)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000*** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.055 (0.977, 1.132) 0.807*** (0.732, 0.881) 1.349*** (1.270, 1.428)
chr15_33001734_T_A_dose:active_met_8751 1.161** (1.067, 1.255) 1.168* (1.024, 1.311) 1.192** (1.066, 1.319) 1.160 (1.000, 1.320)
Constant 0.569** (0.208, 0.930) 0.251*** (-0.308, 0.809) 0.072*** (-0.432, 0.576) 0.393*** (-0.159, 0.945)
Observations 36,958 26,296 27,554 26,333
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.824e-03
LRtest p = 3.354e-02
LRtest p = 6.291e-03
LRtest p = 6.779e-02

GxE model by bmi (CRC)

bmic3 stratified chr15_33001734_T_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Normal (Ca=5027,Co=7768) Overweight (Ca=3423,Co=4413) Obese (Ca=6311,Co=9485)
(1) (2) (3) (4)
chr15_33001734_T_A_dose 1.050 (0.968, 1.132) 1.085 (0.930, 1.240) 0.998 (0.845, 1.152) 1.046 (0.918, 1.175)
active_met_8751 0.803*** (0.736, 0.870) 0.792*** (0.671, 0.914) 0.795** (0.658, 0.932) 0.869** (0.763, 0.974)
age_ref_imp 1.003* (1.000, 1.006) 1.003 (0.999, 1.007) 1.004 (0.998, 1.011) 1.001 (0.996, 1.005)
energytot_imp 1.000*** (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 0.953 (0.864, 1.042) 1.191** (1.075, 1.308) 0.970 (0.891, 1.050)
chr15_33001734_T_A_dose:active_met_8751 1.161** (1.067, 1.255) 1.162 (0.990, 1.334) 1.325** (1.137, 1.513) 1.106 (0.959, 1.252)
Constant 0.569** (0.208, 0.930) 0.452** (-0.122, 1.025) 1.495 (0.513, 2.478) 0.526* (-0.105, 1.157)
Observations 36,958 12,795 7,836 15,796
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.824e-03
LRtest p = 8.779e-02
LRtest p = 3.315e-03
LRtest p = 1.791e-01

Stratified OR

G param by E
Counts (Ca/Co)
TT TA AA TA AA N0 N1 N2
active_met_875=0 1 1.07 (0.97-1.17) 0.98 (0.78-1.24) 1.07 (0.97-1.17) 0.98 (0.78-1.24) 2558.4/3708.9 1280/1759.5 139.6/207.7
p0 P= 1 P= 0.17 P= 0.89 P= 0.17 P= 0.89
active_met_875=1 0.81 (0.76-0.86) 0.98 (0.91-1.05) 1.19 (1.03-1.37) 1.21 (1.15-1.28) 1.47 (1.29-1.69) 7884.9/12259.1 4021.2/5146.3 499/527.7
p1 P= 6.8e-11 P= 0.57 P= 0.019 P= 1.3e-12 P= 2e-08
E param by G
active_met_875 0.81 (0.76-0.86) 0.92 (0.84-1.01) 1.21 (0.93-1.57)
p P= 6.8e-11 P= 0.064 P= 0.16

Locuszoom

Func Annot

chr15_32994756_T_C

Allele freq

GxE model by sex

sex stratified chr15_32994756_C_T_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Female (Ca=8677,Co=12005) Male (Ca=7706,Co=11604)
(1) (2) (3)
chr15_32994756_C_T_dose_flipped 1.000 (0.923, 1.076) 1.040 (0.945, 1.135) 0.934 (0.806, 1.063)
active_met_875Yes 0.794*** (0.730, 0.857) 0.825*** (0.743, 0.908) 0.754*** (0.652, 0.856)
age_ref_imp 1.003* (1.000, 1.005) 1.006** (1.002, 1.009) 1.000 (0.996, 1.003)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.028 (0.977, 1.079)
chr15_32994756_C_T_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.152* (1.038, 1.265) 1.267** (1.125, 1.410)
Constant 0.597** (0.241, 0.952) 0.537* (0.026, 1.047) 0.722 (0.217, 1.227)
Observations 39,992 20,682 19,310
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.272e-05
LRtest p = 1.471e-02
LRtest p = 1.092e-03

GxE model by study design

study_design stratified chr15_32994756_C_T_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Cohort (Ca=10301,Co=18860) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32994756_C_T_dose_flipped 1.000 (0.923, 1.076) 1.012 (0.927, 1.096) 0.932 (0.749, 1.115)
active_met_875Yes 0.794*** (0.730, 0.857) 0.832*** (0.760, 0.903) 0.655*** (0.507, 0.803)
age_ref_imp 1.003* (1.000, 1.005) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.022 (0.957, 1.088) 1.013 (0.932, 1.093)
chr15_32994756_C_T_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.157** (1.057, 1.257) 1.320** (1.123, 1.518)
Constant 0.597** (0.241, 0.952) 1.023 (0.701, 1.344) 0.438*** (-0.019, 0.895)
Observations 39,992 29,161 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.272e-05
LRtest p = 4.286e-03
LRtest p = 5.983e-03

GxE model by tumor site

cancer_site_sum2 stratified chr15_32994756_C_T_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Proximal (Ca=4370,Co=23609) Distal (Ca=5625,Co=23609) Rectal (Ca=4480,Co=23609)
(1) (2) (3) (4)
chr15_32994756_C_T_dose_flipped 1.000 (0.923, 1.076) 0.923 (0.799, 1.047) 1.028 (0.921, 1.135) 1.057 (0.915, 1.198)
active_met_875Yes 0.794*** (0.730, 0.857) 0.710*** (0.608, 0.813) 0.783*** (0.691, 0.875) 0.874* (0.758, 0.991)
age_ref_imp 1.003* (1.000, 1.005) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.048 (0.970, 1.125) 0.802*** (0.727, 0.876) 1.336*** (1.258, 1.414)
chr15_32994756_C_T_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.240** (1.098, 1.382) 1.188** (1.063, 1.312) 1.165 (1.009, 1.321)
Constant 0.597** (0.241, 0.952) 0.259*** (-0.300, 0.817) 0.074*** (-0.430, 0.577) 0.398** (-0.152, 0.949)
Observations 39,992 27,979 29,234 28,089
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.272e-05
LRtest p = 2.749e-03
LRtest p = 6.538e-03
LRtest p = 5.394e-02

GxE model by bmi

bmic3 stratified chr15_32994756_C_T_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Normal (Ca=5528,Co=8430) Overweight (Ca=3672,Co=4735) Obese (Ca=6902,Co=10154)
(1) (2) (3) (4)
chr15_32994756_C_T_dose_flipped 1.000 (0.923, 1.076) 1.012 (0.870, 1.153) 0.972 (0.829, 1.115) 1.000 (0.878, 1.122)
active_met_875Yes 0.794*** (0.730, 0.857) 0.786*** (0.671, 0.900) 0.798*** (0.666, 0.929) 0.848** (0.748, 0.949)
age_ref_imp 1.003* (1.000, 1.005) 1.004 (1.000, 1.008) 1.004 (0.997, 1.010) 1.000 (0.996, 1.004)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 0.963 (0.875, 1.051) 1.168** (1.053, 1.283) 0.976 (0.897, 1.055)
chr15_32994756_C_T_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.223* (1.064, 1.381) 1.265** (1.089, 1.442) 1.151* (1.013, 1.290)
Constant 0.597** (0.241, 0.952) 0.431** (-0.132, 0.993) 1.514 (0.541, 2.486) 0.606 (-0.016, 1.229)
Observations 39,992 13,958 8,407 17,056
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.272e-05
LRtest p = 1.280e-02
LRtest p = 8.896e-03
LRtest p = 4.636e-02

GxE model by sex (CRC)

sex stratified chr15_32994756_T_C_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Female (Ca=7898,Co=11164) Male (Ca=7131,Co=10765)
(1) (2) (3)
chr15_32994756_T_C_dose 0.981 (0.900, 1.062) 0.939 (0.838, 1.040) 1.055 (0.919, 1.192)
active_met_8751 1.099 (0.941, 1.258) 1.060 (0.854, 1.265) 1.197 (0.941, 1.453)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 0.999 (0.996, 1.003)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000** (1.000, 1.000)
sex 1.025 (0.973, 1.076)
chr15_32994756_T_C_dose:active_met_8751 0.851*** (0.759, 0.944) 0.885* (0.766, 1.005) 0.795** (0.645, 0.945)
Constant 0.599** (0.217, 0.981) 0.595 (0.055, 1.136) 0.613 (0.057, 1.169)
Observations 36,958 19,062 17,896
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.586e-04
LRtest p = 4.624e-02
LRtest p = 2.661e-03

GxE model by study design (CRC)

study_design stratified chr15_32994756_T_C_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Cohort (Ca=8947,Co=17180) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32994756_T_C_dose 0.981 (0.900, 1.062) 0.962 (0.871, 1.053) 1.073 (0.890, 1.256)
active_met_8751 1.099 (0.941, 1.258) 1.079 (0.897, 1.262) 1.142 (0.804, 1.480)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.020 (0.953, 1.087) 1.013 (0.932, 1.093)
chr15_32994756_T_C_dose:active_met_8751 0.851*** (0.759, 0.944) 0.883* (0.776, 0.990) 0.757** (0.560, 0.955)
Constant 0.599** (0.217, 0.981) 1.083 (0.715, 1.451) 0.381*** (-0.158, 0.919)
Observations 36,958 26,127 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.586e-04
LRtest p = 2.198e-02
LRtest p = 5.983e-03

GxE model by tumor site (CRC)

cancer_site_sum2 stratified chr15_32994756_T_C_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Proximal (Ca=4367,Co=21929) Distal (Ca=5625,Co=21929) Rectal (Ca=4404,Co=21929)
(1) (2) (3) (4)
chr15_32994756_T_C_dose 0.981 (0.900, 1.062) 1.075 (0.951, 1.200) 0.965 (0.858, 1.073) 0.940 (0.795, 1.084)
active_met_8751 1.099 (0.941, 1.258) 1.082 (0.837, 1.327) 1.098 (0.885, 1.311) 1.177 (0.906, 1.447)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000*** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.054 (0.976, 1.132) 0.806*** (0.731, 0.880) 1.348*** (1.269, 1.427)
chr15_32994756_T_C_dose:active_met_8751 0.851*** (0.759, 0.944) 0.812** (0.670, 0.954) 0.847** (0.722, 0.972) 0.866 (0.707, 1.025)
Constant 0.599** (0.217, 0.981) 0.223*** (-0.369, 0.814) 0.078*** (-0.452, 0.609) 0.452** (-0.141, 1.045)
Observations 36,958 26,296 27,554 26,333
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.586e-04
LRtest p = 3.755e-03
LRtest p = 8.800e-03
LRtest p = 7.459e-02

GxE model by bmi (CRC)

bmic3 stratified chr15_32994756_T_C_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Normal (Ca=5027,Co=7768) Overweight (Ca=3423,Co=4413) Obese (Ca=6311,Co=9485)
(1) (2) (3) (4)
chr15_32994756_T_C_dose 0.981 (0.900, 1.062) 0.969 (0.816, 1.122) 1.007 (0.856, 1.157) 0.976 (0.848, 1.104)
active_met_8751 1.099 (0.941, 1.258) 1.133 (0.843, 1.423) 1.288 (0.970, 1.606) 1.086 (0.837, 1.335)
age_ref_imp 1.003* (1.000, 1.006) 1.003 (0.998, 1.007) 1.004 (0.997, 1.011) 1.001 (0.996, 1.005)
energytot_imp 1.000*** (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 0.951 (0.862, 1.040) 1.190** (1.074, 1.307) 0.971 (0.891, 1.050)
chr15_32994756_T_C_dose:active_met_8751 0.851*** (0.759, 0.944) 0.829* (0.659, 0.999) 0.791* (0.607, 0.976) 0.891 (0.745, 1.036)
Constant 0.599** (0.217, 0.981) 0.491* (-0.129, 1.110) 1.490 (0.480, 2.501) 0.558 (-0.103, 1.218)
Observations 36,958 12,795 7,836 15,796
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.586e-04
LRtest p = 3.005e-02
LRtest p = 1.277e-02
LRtest p = 1.181e-01

Stratified OR

G param by E
Counts (Ca/Co)
CC CT TT CT TT N0 N1 N2
active_met_875=0 1 1.04 (0.94-1.14) 0.89 (0.71-1.12) 1.04 (0.94-1.14) 0.89 (0.71-1.12) 2532.4/3636.4 1303.7/1812 141.9/227.7
p0 P= 1 P= 0.46 P= 0.33 P= 0.46 P= 0.33
active_met_875=1 0.8 (0.75-0.85) 0.95 (0.89-1.02) 1.13 (0.99-1.3) 1.19 (1.13-1.26) 1.42 (1.25-1.61) 7689.9/11947.4 4161.8/5381.5 553.2/604
p1 P= 1.5e-11 P= 0.19 P= 0.076 P= 1.1e-10 P= 9.5e-08
E param by G
active_met_875 0.8 (0.75-0.85) 0.92 (0.84-1.01) 1.27 (0.98-1.64)
p P= 1.5e-11 P= 0.067 P= 0.069

Locuszoom

Func Annot

chr15_32994777_C_T

Allele freq

GxE model by sex

sex stratified chr15_32994777_T_C_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Female (Ca=8677,Co=12005) Male (Ca=7706,Co=11604)
(1) (2) (3)
chr15_32994777_T_C_dose_flipped 1.000 (0.924, 1.077) 1.040 (0.945, 1.135) 0.936 (0.807, 1.065)
active_met_875Yes 0.794*** (0.730, 0.857) 0.825*** (0.742, 0.908) 0.754*** (0.653, 0.856)
age_ref_imp 1.003* (1.000, 1.005) 1.006** (1.002, 1.009) 1.000 (0.996, 1.003)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.028 (0.977, 1.079)
chr15_32994777_T_C_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.153* (1.039, 1.266) 1.266** (1.123, 1.408)
Constant 0.597** (0.241, 0.952) 0.537* (0.026, 1.047) 0.722 (0.217, 1.226)
Observations 39,992 20,682 19,310
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.265e-05
LRtest p = 1.424e-02
LRtest p = 1.159e-03

GxE model by study design

study_design stratified chr15_32994777_T_C_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Cohort (Ca=10301,Co=18860) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32994777_T_C_dose_flipped 1.000 (0.924, 1.077) 1.012 (0.927, 1.096) 0.935 (0.751, 1.118)
active_met_875Yes 0.794*** (0.730, 0.857) 0.831*** (0.760, 0.903) 0.656*** (0.507, 0.804)
age_ref_imp 1.003* (1.000, 1.005) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.022 (0.957, 1.088) 1.013 (0.932, 1.094)
chr15_32994777_T_C_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.157** (1.058, 1.257) 1.317** (1.119, 1.515)
Constant 0.597** (0.241, 0.952) 1.022 (0.701, 1.344) 0.438*** (-0.020, 0.895)
Observations 39,992 29,161 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.265e-05
LRtest p = 4.096e-03
LRtest p = 6.460e-03

GxE model by tumor site

cancer_site_sum2 stratified chr15_32994777_T_C_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Proximal (Ca=4370,Co=23609) Distal (Ca=5625,Co=23609) Rectal (Ca=4480,Co=23609)
(1) (2) (3) (4)
chr15_32994777_T_C_dose_flipped 1.000 (0.924, 1.077) 0.923 (0.799, 1.047) 1.030 (0.923, 1.137) 1.057 (0.915, 1.198)
active_met_875Yes 0.794*** (0.730, 0.857) 0.710*** (0.608, 0.812) 0.783*** (0.691, 0.876) 0.874* (0.758, 0.991)
age_ref_imp 1.003* (1.000, 1.005) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.048 (0.970, 1.125) 0.802*** (0.727, 0.876) 1.336*** (1.258, 1.414)
chr15_32994777_T_C_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.241** (1.099, 1.383) 1.186** (1.062, 1.311) 1.166 (1.010, 1.322)
Constant 0.597** (0.241, 0.952) 0.259*** (-0.300, 0.817) 0.074*** (-0.430, 0.577) 0.398** (-0.152, 0.949)
Observations 39,992 27,979 29,234 28,089
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.265e-05
LRtest p = 2.681e-03
LRtest p = 6.960e-03
LRtest p = 5.256e-02

GxE model by bmi

bmic3 stratified chr15_32994777_T_C_dose_flipped x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Normal (Ca=5528,Co=8430) Overweight (Ca=3672,Co=4735) Obese (Ca=6902,Co=10154)
(1) (2) (3) (4)
chr15_32994777_T_C_dose_flipped 1.000 (0.924, 1.077) 1.011 (0.869, 1.152) 0.974 (0.831, 1.117) 1.001 (0.879, 1.123)
active_met_875Yes 0.794*** (0.730, 0.857) 0.785*** (0.671, 0.900) 0.798*** (0.667, 0.929) 0.848** (0.748, 0.949)
age_ref_imp 1.003* (1.000, 1.005) 1.004 (1.000, 1.008) 1.004 (0.997, 1.010) 1.000 (0.996, 1.004)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 0.963 (0.875, 1.051) 1.168** (1.053, 1.283) 0.976 (0.897, 1.055)
chr15_32994777_T_C_dose_flipped:active_met_875Yes 1.192*** (1.104, 1.279) 1.224* (1.066, 1.383) 1.264** (1.087, 1.440) 1.151* (1.012, 1.290)
Constant 0.597** (0.241, 0.952) 0.431** (-0.131, 0.993) 1.513 (0.540, 2.485) 0.606 (-0.016, 1.229)
Observations 39,992 13,958 8,407 17,056
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.265e-05
LRtest p = 1.226e-02
LRtest p = 9.324e-03
LRtest p = 4.642e-02

GxE model by sex (CRC)

sex stratified chr15_32994777_C_T_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Female (Ca=7898,Co=11164) Male (Ca=7131,Co=10765)
(1) (2) (3)
chr15_32994777_C_T_dose 0.980 (0.899, 1.061) 0.939 (0.838, 1.040) 1.054 (0.918, 1.190)
active_met_8751 1.099 (0.941, 1.258) 1.061 (0.855, 1.266) 1.194 (0.938, 1.451)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 0.999 (0.996, 1.003)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000** (1.000, 1.000)
sex 1.025 (0.973, 1.076)
chr15_32994777_C_T_dose:active_met_8751 0.851*** (0.759, 0.944) 0.885* (0.765, 1.005) 0.796** (0.646, 0.946)
Constant 0.599** (0.217, 0.982) 0.595 (0.054, 1.135) 0.615 (0.059, 1.171)
Observations 36,958 19,062 17,896
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.632e-04
LRtest p = 4.511e-02
LRtest p = 2.825e-03

GxE model by study design (CRC)

study_design stratified chr15_32994777_C_T_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Cohort (Ca=8947,Co=17180) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32994777_C_T_dose 0.980 (0.899, 1.061) 0.962 (0.872, 1.053) 1.070 (0.887, 1.253)
active_met_8751 1.099 (0.941, 1.258) 1.081 (0.898, 1.263) 1.137 (0.800, 1.475)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.020 (0.953, 1.087) 1.013 (0.932, 1.094)
chr15_32994777_C_T_dose:active_met_8751 0.851*** (0.759, 0.944) 0.882* (0.775, 0.989) 0.759** (0.561, 0.957)
Constant 0.599** (0.217, 0.982) 1.083 (0.715, 1.451) 0.382*** (-0.156, 0.921)
Observations 36,958 26,127 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.632e-04
LRtest p = 2.121e-02
LRtest p = 6.460e-03

GxE model by tumor site (CRC)

cancer_site_sum2 stratified chr15_32994777_C_T_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Proximal (Ca=4367,Co=21929) Distal (Ca=5625,Co=21929) Rectal (Ca=4404,Co=21929)
(1) (2) (3) (4)
chr15_32994777_C_T_dose 0.980 (0.899, 1.061) 1.076 (0.951, 1.200) 0.964 (0.857, 1.071) 0.940 (0.795, 1.084)
active_met_8751 1.099 (0.941, 1.258) 1.083 (0.838, 1.328) 1.096 (0.883, 1.309) 1.178 (0.908, 1.449)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000*** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.054 (0.976, 1.132) 0.806*** (0.731, 0.880) 1.348*** (1.269, 1.427)
chr15_32994777_C_T_dose:active_met_8751 0.851*** (0.759, 0.944) 0.811** (0.669, 0.953) 0.848** (0.723, 0.973) 0.865 (0.706, 1.024)
Constant 0.599** (0.217, 0.982) 0.222*** (-0.369, 0.814) 0.079*** (-0.452, 0.609) 0.452** (-0.141, 1.045)
Observations 36,958 26,296 27,554 26,333
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.632e-04
LRtest p = 3.667e-03
LRtest p = 9.355e-03
LRtest p = 7.276e-02

GxE model by bmi (CRC)

bmic3 stratified chr15_32994777_C_T_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Normal (Ca=5027,Co=7768) Overweight (Ca=3423,Co=4413) Obese (Ca=6311,Co=9485)
(1) (2) (3) (4)
chr15_32994777_C_T_dose 0.980 (0.899, 1.061) 0.970 (0.817, 1.123) 1.005 (0.855, 1.155) 0.975 (0.847, 1.104)
active_met_8751 1.099 (0.941, 1.258) 1.136 (0.845, 1.426) 1.285 (0.967, 1.603) 1.085 (0.837, 1.334)
age_ref_imp 1.003* (1.000, 1.006) 1.003 (0.998, 1.007) 1.004 (0.997, 1.011) 1.001 (0.996, 1.005)
energytot_imp 1.000*** (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 0.951 (0.862, 1.040) 1.190** (1.074, 1.307) 0.971 (0.891, 1.050)
chr15_32994777_C_T_dose:active_met_8751 0.851*** (0.759, 0.944) 0.827* (0.657, 0.997) 0.792* (0.608, 0.977) 0.891 (0.745, 1.036)
Constant 0.599** (0.217, 0.982) 0.490* (-0.129, 1.109) 1.495 (0.484, 2.505) 0.558 (-0.103, 1.218)
Observations 36,958 12,795 7,836 15,796
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 6.632e-04
LRtest p = 2.885e-02
LRtest p = 1.336e-02
LRtest p = 1.190e-01

Stratified OR

G param by E
Counts (Ca/Co)
TT TC CC TC CC N0 N1 N2
active_met_875=0 1 1.04 (0.94-1.14) 0.89 (0.71-1.12) 1.04 (0.94-1.14) 0.89 (0.71-1.12) 2531.6/3635.7 1304.5/1812.5 142/227.7
p0 P= 1 P= 0.46 P= 0.34 P= 0.46 P= 0.34
active_met_875=1 0.8 (0.75-0.85) 0.95 (0.89-1.02) 1.13 (0.99-1.3) 1.19 (1.13-1.26) 1.42 (1.25-1.61) 7688.3/11946.8 4163.4/5382 553.3/604.2
p1 P= 1.5e-11 P= 0.19 P= 0.075 P= 9.3e-11 P= 9.4e-08
E param by G
active_met_875 0.8 (0.75-0.85) 0.92 (0.84-1.01) 1.27 (0.98-1.64)
p P= 1.5e-11 P= 0.067 P= 0.07

Locuszoom

Func Annot

chr15_32995298_C_A

Allele freq

GxE model by sex

sex stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Female (Ca=8677,Co=12005) Male (Ca=7706,Co=11604)
(1) (2) (3)
chr15_32995298_C_A_dose 1.012 (0.934, 1.090) 1.038 (0.940, 1.135) 0.971 (0.840, 1.103)
active_met_875Yes 0.797*** (0.734, 0.860) 0.827*** (0.745, 0.909) 0.763*** (0.662, 0.864)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 1.000 (0.996, 1.003)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.028 (0.977, 1.079)
chr15_32995298_C_A_dose:active_met_875Yes 1.192*** (1.102, 1.282) 1.157* (1.041, 1.273) 1.248** (1.102, 1.393)
Constant 0.592** (0.237, 0.947) 0.536* (0.026, 1.046) 0.709 (0.204, 1.213)
Observations 39,992 20,682 19,310
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.275e-04
LRtest p = 1.373e-02
LRtest p = 2.882e-03

GxE model by study design

study_design stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Cohort (Ca=10301,Co=18860) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32995298_C_A_dose 1.012 (0.934, 1.090) 1.017 (0.931, 1.104) 0.977 (0.790, 1.164)
active_met_8751 0.797*** (0.734, 0.860) 0.833*** (0.762, 0.903) 0.668*** (0.521, 0.814)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.022 (0.957, 1.088) 1.014 (0.933, 1.094)
chr15_32995298_C_A_dose:active_met_8751 1.192*** (1.102, 1.282) 1.163** (1.061, 1.266) 1.280* (1.078, 1.482)
Constant 0.592** (0.237, 0.947) 1.017 (0.695, 1.339) 0.428*** (-0.028, 0.885)
Observations 39,992 29,161 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.275e-04
LRtest p = 3.728e-03
LRtest p = 1.701e-02

GxE model by tumor site

cancer_site_sum2 stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Proximal (Ca=4370,Co=23609) Distal (Ca=5625,Co=23609) Rectal (Ca=4480,Co=23609)
(1) (2) (3) (4)
chr15_32995298_C_A_dose 1.012 (0.934, 1.090) 0.946 (0.819, 1.072) 1.036 (0.927, 1.145) 1.062 (0.918, 1.207)
active_met_8751 0.797*** (0.734, 0.860) 0.721*** (0.620, 0.822) 0.783*** (0.692, 0.875) 0.872* (0.757, 0.988)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.048 (0.971, 1.126) 0.802*** (0.728, 0.877) 1.337*** (1.259, 1.415)
chr15_32995298_C_A_dose:active_met_8751 1.192*** (1.102, 1.282) 1.207* (1.062, 1.352) 1.199** (1.072, 1.326) 1.184* (1.024, 1.343)
Constant 0.592** (0.237, 0.947) 0.255*** (-0.303, 0.813) 0.073*** (-0.431, 0.577) 0.394*** (-0.156, 0.945)
Observations 39,992 27,979 29,234 28,089
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.275e-04
LRtest p = 1.051e-02
LRtest p = 5.050e-03
LRtest p = 3.703e-02

GxE model by bmi

bmic3 stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Normal (Ca=5528,Co=8430) Overweight (Ca=3672,Co=4735) Obese (Ca=6902,Co=10154)
(1) (2) (3) (4)
chr15_32995298_C_A_dose 1.012 (0.934, 1.090) 1.031 (0.885, 1.177) 0.956 (0.809, 1.103) 1.014 (0.891, 1.138)
active_met_8751 0.797*** (0.734, 0.860) 0.791*** (0.678, 0.904) 0.789*** (0.659, 0.919) 0.854** (0.754, 0.953)
age_ref_imp 1.003* (1.000, 1.006) 1.004 (1.000, 1.008) 1.004 (0.997, 1.010) 1.000 (0.996, 1.004)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 0.965 (0.877, 1.053) 1.168** (1.053, 1.283) 0.976 (0.897, 1.055)
chr15_32995298_C_A_dose:active_met_8751 1.192*** (1.102, 1.282) 1.216* (1.053, 1.380) 1.323** (1.142, 1.504) 1.144 (1.003, 1.285)
Constant 0.592** (0.237, 0.947) 0.426** (-0.136, 0.989) 1.511 (0.539, 2.483) 0.602 (-0.020, 1.225)
Observations 39,992 13,958 8,407 17,056
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.275e-04
LRtest p = 1.852e-02
LRtest p = 2.438e-03
LRtest p = 6.167e-02

GxE model by sex (CRC)

sex stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Female (Ca=7898,Co=11164) Male (Ca=7131,Co=10765)
(1) (2) (3)
chr15_32995298_C_A_dose 1.032 (0.949, 1.114) 1.054 (0.951, 1.157) 0.998 (0.858, 1.137)
active_met_8751 0.800*** (0.733, 0.867) 0.830*** (0.743, 0.917) 0.769*** (0.663, 0.876)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 0.999 (0.996, 1.003)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000** (1.000, 1.000)
sex 1.025 (0.973, 1.076)
chr15_32995298_C_A_dose:active_met_8751 1.174*** (1.080, 1.269) 1.141* (1.019, 1.263) 1.222* (1.068, 1.376)
Constant 0.572** (0.211, 0.933) 0.526* (0.009, 1.043) 0.667 (0.152, 1.182)
Observations 36,958 19,062 17,896
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 8.777e-04
LRtest p = 3.404e-02
LRtest p = 1.033e-02

GxE model by study design (CRC)

study_design stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Cohort (Ca=8947,Co=17180) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32995298_C_A_dose 1.032 (0.949, 1.114) 1.043 (0.951, 1.136) 0.977 (0.790, 1.164)
active_met_8751 0.800*** (0.733, 0.867) 0.842*** (0.766, 0.918) 0.668*** (0.521, 0.814)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.020 (0.953, 1.087) 1.014 (0.933, 1.094)
chr15_32995298_C_A_dose:active_met_8751 1.174*** (1.080, 1.269) 1.138* (1.029, 1.248) 1.280* (1.078, 1.482)
Constant 0.572** (0.211, 0.933) 0.998 (0.656, 1.339) 0.428*** (-0.028, 0.885)
Observations 36,958 26,127 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 8.777e-04
LRtest p = 1.986e-02
LRtest p = 1.701e-02

GxE model by tumor site (CRC)

cancer_site_sum2 stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Proximal (Ca=4367,Co=21929) Distal (Ca=5625,Co=21929) Rectal (Ca=4404,Co=21929)
(1) (2) (3) (4)
chr15_32995298_C_A_dose 1.032 (0.949, 1.114) 0.953 (0.826, 1.079) 1.044 (0.934, 1.153) 1.074 (0.927, 1.221)
active_met_8751 0.800*** (0.733, 0.867) 0.724*** (0.622, 0.825) 0.788*** (0.696, 0.879) 0.882* (0.765, 0.999)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000*** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.055 (0.977, 1.132) 0.807*** (0.732, 0.881) 1.349*** (1.270, 1.428)
chr15_32995298_C_A_dose:active_met_8751 1.174*** (1.080, 1.269) 1.199* (1.054, 1.344) 1.191** (1.064, 1.319) 1.167 (1.005, 1.330)
Constant 0.572** (0.211, 0.933) 0.254*** (-0.305, 0.812) 0.072*** (-0.432, 0.576) 0.395*** (-0.157, 0.946)
Observations 36,958 26,296 27,554 26,333
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 8.777e-04
LRtest p = 1.356e-02
LRtest p = 6.926e-03
LRtest p = 5.954e-02

GxE model by bmi (CRC)

bmic3 stratified chr15_32995298_C_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Normal (Ca=5027,Co=7768) Overweight (Ca=3423,Co=4413) Obese (Ca=6311,Co=9485)
(1) (2) (3) (4)
chr15_32995298_C_A_dose 1.032 (0.949, 1.114) 1.042 (0.885, 1.199) 0.977 (0.823, 1.130) 1.044 (0.914, 1.174)
active_met_8751 0.800*** (0.733, 0.867) 0.781*** (0.660, 0.902) 0.798** (0.661, 0.934) 0.868** (0.763, 0.973)
age_ref_imp 1.003* (1.000, 1.006) 1.003 (0.999, 1.007) 1.004 (0.997, 1.011) 1.001 (0.996, 1.005)
energytot_imp 1.000*** (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 0.953 (0.864, 1.041) 1.190** (1.074, 1.307) 0.971 (0.891, 1.050)
chr15_32995298_C_A_dose:active_met_8751 1.174*** (1.080, 1.269) 1.209* (1.035, 1.384) 1.320** (1.131, 1.509) 1.109 (0.961, 1.257)
Constant 0.572** (0.211, 0.933) 0.458** (-0.115, 1.031) 1.507 (0.526, 2.489) 0.527* (-0.104, 1.157)
Observations 36,958 12,795 7,836 15,796
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 8.777e-04
LRtest p = 3.264e-02
LRtest p = 3.897e-03
LRtest p = 1.690e-01

Stratified OR

G param by E
Counts (Ca/Co)
CC CA AA CA AA N0 N1 N2
active_met_875=0 1 1.04 (0.94-1.14) 0.95 (0.74-1.2) 1.04 (0.94-1.14) 0.95 (0.74-1.2) 2602.3/3742.8 1244.6/1737.4 131.2/195.8
p0 P= 1 P= 0.46 P= 0.65 P= 0.46 P= 0.65
active_met_875=1 0.8 (0.75-0.85) 0.96 (0.9-1.04) 1.17 (1.01-1.35) 1.21 (1.14-1.27) 1.46 (1.28-1.68) 7930.5/12310.9 3985.9/5110 488.5/512.1
p1 P= 1.2e-11 P= 0.33 P= 0.033 P= 1.1e-11 P= 5.2e-08
E param by G
active_met_875 0.8 (0.75-0.85) 0.93 (0.85-1.02) 1.24 (0.94-1.62)
p P= 1.2e-11 P= 0.13 P= 0.12

Locuszoom

Func Annot

chr15_32995764_C_G

Allele freq

GxE model by sex

sex stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Female (Ca=8677,Co=12005) Male (Ca=7706,Co=11604)
(1) (2) (3)
chr15_32995764_C_G_dose 1.014 (0.936, 1.093) 1.041 (0.943, 1.138) 0.972 (0.840, 1.103)
active_met_875Yes 0.797*** (0.734, 0.861) 0.828*** (0.746, 0.910) 0.763*** (0.662, 0.864)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 1.000 (0.996, 1.003)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.028 (0.977, 1.079)
chr15_32995764_C_G_dose:active_met_875Yes 1.190*** (1.100, 1.280) 1.154* (1.038, 1.270) 1.248** (1.102, 1.394)
Constant 0.592** (0.236, 0.947) 0.536* (0.026, 1.046) 0.708 (0.204, 1.213)
Observations 39,992 20,682 19,310
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.476e-04
LRtest p = 1.559e-02
LRtest p = 2.876e-03

GxE model by study design

study_design stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Cohort (Ca=10301,Co=18860) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32995764_C_G_dose 1.014 (0.936, 1.093) 1.020 (0.933, 1.106) 0.977 (0.790, 1.164)
active_met_8751 0.797*** (0.734, 0.861) 0.834*** (0.763, 0.904) 0.667*** (0.521, 0.814)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.022 (0.957, 1.088) 1.014 (0.933, 1.094)
chr15_32995764_C_G_dose:active_met_8751 1.190*** (1.100, 1.280) 1.160** (1.058, 1.263) 1.282* (1.080, 1.484)
Constant 0.592** (0.236, 0.947) 1.016 (0.694, 1.338) 0.429*** (-0.028, 0.885)
Observations 39,992 29,161 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.476e-04
LRtest p = 4.400e-03
LRtest p = 1.622e-02

GxE model by tumor site

cancer_site_sum2 stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Proximal (Ca=4370,Co=23609) Distal (Ca=5625,Co=23609) Rectal (Ca=4480,Co=23609)
(1) (2) (3) (4)
chr15_32995764_C_G_dose 1.014 (0.936, 1.093) 0.947 (0.821, 1.074) 1.039 (0.930, 1.148) 1.064 (0.920, 1.209)
active_met_8751 0.797*** (0.734, 0.861) 0.721*** (0.620, 0.823) 0.784*** (0.693, 0.876) 0.873* (0.758, 0.988)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 1.048 (0.971, 1.126) 0.802*** (0.728, 0.877) 1.337*** (1.259, 1.415)
chr15_32995764_C_G_dose:active_met_8751 1.190*** (1.100, 1.280) 1.206* (1.061, 1.351) 1.196** (1.069, 1.323) 1.183* (1.023, 1.342)
Constant 0.592** (0.236, 0.947) 0.255*** (-0.304, 0.813) 0.073*** (-0.431, 0.577) 0.394*** (-0.156, 0.944)
Observations 39,992 27,979 29,234 28,089
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.476e-04
LRtest p = 1.081e-02
LRtest p = 5.704e-03
LRtest p = 3.781e-02

GxE model by bmi

bmic3 stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Normal (Ca=5528,Co=8430) Overweight (Ca=3672,Co=4735) Obese (Ca=6902,Co=10154)
(1) (2) (3) (4)
chr15_32995764_C_G_dose 1.014 (0.936, 1.093) 1.038 (0.892, 1.184) 0.955 (0.808, 1.102) 1.015 (0.892, 1.139)
active_met_8751 0.797*** (0.734, 0.861) 0.793*** (0.681, 0.906) 0.788*** (0.657, 0.918) 0.854** (0.754, 0.954)
age_ref_imp 1.003* (1.000, 1.006) 1.004 (1.000, 1.008) 1.004 (0.997, 1.010) 1.000 (0.996, 1.004)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.028 (0.977, 1.079) 0.965 (0.877, 1.053) 1.168** (1.053, 1.283) 0.976 (0.897, 1.055)
chr15_32995764_C_G_dose:active_met_8751 1.190*** (1.100, 1.280) 1.207* (1.043, 1.370) 1.329** (1.148, 1.511) 1.143 (1.002, 1.284)
Constant 0.592** (0.236, 0.947) 0.425** (-0.137, 0.987) 1.511 (0.539, 2.483) 0.602 (-0.021, 1.224)
Observations 39,992 13,958 8,407 17,056
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.476e-04
LRtest p = 2.417e-02
LRtest p = 2.048e-03
LRtest p = 6.301e-02

GxE model by sex (CRC)

sex stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Female (Ca=7898,Co=11164) Male (Ca=7131,Co=10765)
(1) (2) (3)
chr15_32995764_C_G_dose 1.034 (0.951, 1.117) 1.058 (0.955, 1.161) 0.998 (0.859, 1.137)
active_met_8751 0.801*** (0.734, 0.868) 0.831*** (0.744, 0.918) 0.769*** (0.663, 0.876)
age_ref_imp 1.003* (1.000, 1.006) 1.006** (1.002, 1.010) 0.999 (0.996, 1.003)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000** (1.000, 1.000)
sex 1.025 (0.973, 1.076)
chr15_32995764_C_G_dose:active_met_8751 1.172** (1.077, 1.267) 1.138* (1.015, 1.260) 1.222* (1.069, 1.376)
Constant 0.571** (0.210, 0.932) 0.525* (0.008, 1.043) 0.666 (0.151, 1.181)
Observations 36,958 19,062 17,896
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.009e-03
LRtest p = 3.866e-02
LRtest p = 1.022e-02

GxE model by study design (CRC)

study_design stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Cohort (Ca=8947,Co=17180) Case-Control (Ca=6082,Co=4749)
(1) (2) (3)
chr15_32995764_C_G_dose 1.034 (0.951, 1.117) 1.046 (0.954, 1.139) 0.977 (0.790, 1.164)
active_met_8751 0.801*** (0.734, 0.868) 0.843*** (0.767, 0.919) 0.667*** (0.521, 0.814)
age_ref_imp 1.003* (1.000, 1.006) 1.002 (0.998, 1.006) 1.004* (1.000, 1.008)
energytot_imp 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.020 (0.953, 1.087) 1.014 (0.933, 1.094)
chr15_32995764_C_G_dose:active_met_8751 1.172** (1.077, 1.267) 1.135* (1.026, 1.244) 1.282* (1.080, 1.484)
Constant 0.571** (0.210, 0.932) 0.996 (0.655, 1.338) 0.429*** (-0.028, 0.885)
Observations 36,958 26,127 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.009e-03
LRtest p = 2.305e-02
LRtest p = 1.622e-02

GxE model by tumor site (CRC)

cancer_site_sum2 stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Proximal (Ca=4367,Co=21929) Distal (Ca=5625,Co=21929) Rectal (Ca=4404,Co=21929)
(1) (2) (3) (4)
chr15_32995764_C_G_dose 1.034 (0.951, 1.117) 0.955 (0.828, 1.081) 1.046 (0.937, 1.156) 1.076 (0.929, 1.223)
active_met_8751 0.801*** (0.734, 0.868) 0.724*** (0.622, 0.826) 0.789*** (0.697, 0.880) 0.882* (0.765, 0.999)
age_ref_imp 1.003* (1.000, 1.006) 0.998 (0.994, 1.002) 1.022*** (1.019, 1.026) 0.986*** (0.982, 0.990)
energytot_imp 1.000*** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000** (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 1.055 (0.977, 1.132) 0.807*** (0.732, 0.881) 1.349*** (1.270, 1.427)
chr15_32995764_C_G_dose:active_met_8751 1.172** (1.077, 1.267) 1.198* (1.053, 1.344) 1.188** (1.061, 1.316) 1.167 (1.005, 1.329)
Constant 0.571** (0.210, 0.932) 0.253*** (-0.305, 0.812) 0.072*** (-0.432, 0.576) 0.394*** (-0.157, 0.946)
Observations 36,958 26,296 27,554 26,333
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.009e-03
LRtest p = 1.392e-02
LRtest p = 7.796e-03
LRtest p = 6.065e-02

GxE model by bmi (CRC)

bmic3 stratified chr15_32995764_C_G_dose x active_met_875
Dependent variable:
outcome
All (Ca=15029,Co=21929) Normal (Ca=5027,Co=7768) Overweight (Ca=3423,Co=4413) Obese (Ca=6311,Co=9485)
(1) (2) (3) (4)
chr15_32995764_C_G_dose 1.034 (0.951, 1.117) 1.050 (0.893, 1.207) 0.976 (0.822, 1.130) 1.045 (0.915, 1.175)
active_met_8751 0.801*** (0.734, 0.868) 0.783*** (0.662, 0.905) 0.796** (0.660, 0.933) 0.868** (0.763, 0.973)
age_ref_imp 1.003* (1.000, 1.006) 1.003 (0.999, 1.007) 1.004 (0.997, 1.011) 1.001 (0.996, 1.005)
energytot_imp 1.000*** (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.025 (0.973, 1.076) 0.953 (0.864, 1.041) 1.190** (1.074, 1.307) 0.971 (0.891, 1.050)
chr15_32995764_C_G_dose:active_met_8751 1.172** (1.077, 1.267) 1.199* (1.024, 1.373) 1.327** (1.138, 1.516) 1.108 (0.961, 1.256)
Constant 0.571** (0.210, 0.932) 0.456** (-0.117, 1.029) 1.507 (0.525, 2.489) 0.526* (-0.105, 1.157)
Observations 36,958 12,795 7,836 15,796
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.009e-03
LRtest p = 4.206e-02
LRtest p = 3.336e-03
LRtest p = 1.718e-01

Stratified OR

G param by E
Counts (Ca/Co)
CC CG GG CG GG N0 N1 N2
active_met_875=0 1 1.04 (0.94-1.14) 0.95 (0.75-1.21) 1.04 (0.94-1.14) 0.95 (0.75-1.21) 2601.7/3744.7 1245.1/1736.3 131.2/195
p0 P= 1 P= 0.44 P= 0.68 P= 0.44 P= 0.68
active_met_875=1 0.8 (0.75-0.85) 0.97 (0.9-1.04) 1.18 (1.02-1.36) 1.2 (1.14-1.27) 1.47 (1.28-1.69) 7932.2/12314.4 3984/5107.6 488.9/510.9
p1 P= 1.4e-11 P= 0.33 P= 0.028 P= 1.3e-11 P= 3.7e-08
E param by G
active_met_875 0.8 (0.75-0.85) 0.93 (0.85-1.02) 1.24 (0.94-1.62)
p P= 1.4e-11 P= 0.12 P= 0.12

Locuszoom

Func Annot

E|G finding (combined case-control sample)

chr13_61572969_G_A

Allele freq

E|G model by sex

sex stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
outcome
All (Ca=16383,Co=23609) Female (Ca=8677,Co=12005) Male (Ca=7706,Co=11604)
(1) (2) (3)
chr13_61572969_G_A_dose 0.943 (0.857, 1.029) 0.919 (0.814, 1.024) 0.995 (0.845, 1.144)
active_met_875Yes 0.829*** (0.768, 0.889) 0.844*** (0.765, 0.923) 0.820*** (0.723, 0.917)
age_ref_imp 1.003* (1.000, 1.005) 1.006** (1.002, 1.009) 1.000 (0.996, 1.003)
energytot_imp 1.000** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.028 (0.977, 1.079)
chr13_61572969_G_A_dose:active_met_875Yes 1.086 (0.988, 1.184) 1.114 (0.989, 1.239) 1.029 (0.865, 1.193)
Constant 0.613** (0.258, 0.968) 0.568* (0.058, 1.077) 0.708 (0.204, 1.212)
Observations 39,992 20,682 19,310
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 9.963e-02
LRtest p = 8.979e-02
LRtest p = 7.311e-01

E|G model by study design

study_design stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Cohort (Ca=,Co=) Case-Control (Ca=,Co=)
(1) (2) (3)
chr13_61572969_G_A_dose 1.022*** (1.014, 1.029) 1.025*** (1.016, 1.034) 1.013* (1.001, 1.025)
age_ref_imp 1.000 (0.999, 1.000) 1.000 (1.000, 1.001) 0.999*** (0.998, 1.000)
energytot_imp 1.000* (1.000, 1.000) 1.000* (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.039*** (1.030, 1.048) 1.069*** (1.057, 1.081) 0.982** (0.970, 0.995)
Constant 4.616*** (4.548, 4.685) 5.218*** (5.155, 5.281) 4.952*** (4.883, 5.020)
Observations 39,992 29,161 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 3.179e-08
LRtest p = 3.211e-07
LRtest p = 3.721e-02

E|G model by tumor site

cancer_site_sum2 stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Proximal (Ca=,Co=) Distal (Ca=,Co=) Rectal (Ca=,Co=)
(1) (2) (3) (4)
chr13_61572969_G_A_dose 1.022*** (1.014, 1.029) 1.020*** (1.011, 1.029) 1.019*** (1.010, 1.028) 1.018*** (1.009, 1.027)
age_ref_imp 1.000 (0.999, 1.000) 1.000 (0.999, 1.001) 1.000 (0.999, 1.000) 1.000 (0.999, 1.000)
energytot_imp 1.000* (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.039*** (1.030, 1.048) 1.049*** (1.038, 1.060) 1.051*** (1.040, 1.061) 1.048*** (1.037, 1.058)
Constant 4.616*** (4.548, 4.685) 4.706*** (4.622, 4.789) 4.726*** (4.645, 4.807) 4.902*** (4.821, 4.983)
Observations 39,992 27,979 29,234 28,089
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 3.179e-08
LRtest p = 2.678e-05
LRtest p = 3.537e-05
LRtest p = 9.689e-05

E|G model by bmi

bmic3 stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Normal (Ca=,Co=) Overweight (Ca=,Co=) Obese (Ca=,Co=)
(1) (2) (3) (4)
chr13_61572969_G_A_dose 1.022*** (1.014, 1.029) 1.018** (1.006, 1.031) 1.022* (1.004, 1.040) 1.024*** (1.012, 1.035)
age_ref_imp 1.000 (0.999, 1.000) 1.000 (0.999, 1.000) 1.001 (1.000, 1.002) 1.000 (0.999, 1.001)
energytot_imp 1.000* (1.000, 1.000) 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.039*** (1.030, 1.048) 1.014 (0.999, 1.028) 1.081*** (1.059, 1.103) 1.053*** (1.039, 1.066)
Constant 4.616*** (4.548, 4.685) 5.013*** (4.913, 5.113) 2.731*** (2.536, 2.926) 5.064*** (4.948, 5.180)
Observations 39,992 13,958 8,407 17,056
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 3.179e-08
LRtest p = 3.378e-03
LRtest p = 1.539e-02
LRtest p = 6.899e-05

E|G model by sex (CRC)

sex stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Female (Ca=,Co=) Male (Ca=,Co=)
(1) (2) (3)
chr13_61572969_G_A_dose 1.021*** (1.014, 1.029) 1.027*** (1.016, 1.039) 1.016** (1.005, 1.026)
age_ref_imp 1.000 (0.999, 1.000) 0.999* (0.998, 1.000) 1.000 (0.999, 1.001)
energytot_imp 1.000 (1.000, 1.000) 1.000* (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.039*** (1.030, 1.048)
Constant 4.706*** (4.638, 4.775) 4.848*** (4.744, 4.952) 4.725*** (4.635, 4.815)
Observations 36,958 19,062 17,896
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.147e-07
LRtest p = 4.003e-06
LRtest p = 3.672e-03

E|G model by study design (CRC)

study_design stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Cohort (Ca=,Co=) Case-Control (Ca=,Co=)
(1) (2) (3)
chr13_61572969_G_A_dose 1.021*** (1.014, 1.029) 1.025*** (1.015, 1.035) 1.013* (1.001, 1.025)
age_ref_imp 1.000 (0.999, 1.000) 1.000 (0.999, 1.001) 0.999*** (0.998, 1.000)
energytot_imp 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000* (1.000, 1.000)
sex 1.039*** (1.030, 1.048) 1.070*** (1.058, 1.082) 0.982** (0.970, 0.995)
Constant 4.706*** (4.638, 4.775) 5.365*** (5.299, 5.431) 4.952*** (4.883, 5.020)
Observations 36,958 26,127 10,831
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.147e-07
LRtest p = 1.104e-06
LRtest p = 3.721e-02

E|G model by tumor site (CRC)

cancer_site_sum2 stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Proximal (Ca=,Co=) Distal (Ca=,Co=) Rectal (Ca=,Co=)
(1) (2) (3) (4)
chr13_61572969_G_A_dose 1.021*** (1.014, 1.029) 1.020*** (1.011, 1.029) 1.020*** (1.010, 1.029) 1.018*** (1.009, 1.027)
age_ref_imp 1.000 (0.999, 1.000) 1.000 (0.999, 1.001) 0.999 (0.999, 1.000) 1.000 (0.999, 1.000)
energytot_imp 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.039*** (1.030, 1.048) 1.050*** (1.039, 1.060) 1.051*** (1.040, 1.062) 1.048*** (1.037, 1.059)
Constant 4.706*** (4.638, 4.775) 4.792*** (4.709, 4.876) 4.814*** (4.732, 4.896) 4.991*** (4.910, 5.072)
Observations 36,958 26,296 27,554 26,333
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.147e-07
LRtest p = 3.521e-05
LRtest p = 3.878e-05
LRtest p = 1.193e-04

E|G model by bmi (CRC)

bmic3 stratified chr13_61572969_G_A_dose x active_met_875
Dependent variable:
exposure_num
All (Ca=,Co=) Normal (Ca=,Co=) Overweight (Ca=,Co=) Obese (Ca=,Co=)
(1) (2) (3) (4)
chr13_61572969_G_A_dose 1.021*** (1.014, 1.029) 1.022*** (1.009, 1.034) 1.026** (1.007, 1.044) 1.018** (1.007, 1.030)
age_ref_imp 1.000 (0.999, 1.000) 0.999 (0.999, 1.000) 1.001 (0.999, 1.002) 1.000 (0.999, 1.000)
energytot_imp 1.000 (1.000, 1.000) 1.000*** (1.000, 1.000) 1.000 (1.000, 1.000) 1.000 (1.000, 1.000)
sex 1.039*** (1.030, 1.048) 1.012 (0.997, 1.027) 1.082*** (1.060, 1.103) 1.053*** (1.039, 1.067)
Constant 4.706*** (4.638, 4.775) 5.131*** (5.031, 5.231) 2.811*** (2.616, 3.006) 5.119*** (5.003, 5.236)
Observations 36,958 12,795 7,836 15,796
Note: p<0.05; p<0.01; p<0.001
(PC and Study estimates omitted from table)
LRtest p = 1.147e-07
LRtest p = 7.993e-04
LRtest p = 6.296e-03
LRtest p = 2.515e-03

Stratified OR

G param by E
Counts (Ca/Co)
GG GA AA GA AA N0 N1 N2
active_met_875=0 1 0.97 (0.88-1.08) 0.77 (0.58-1.04) 0.97 (0.88-1.08) 0.77 (0.58-1.04) 2947.7/4130.3 949.1/1402.6 81.2/143.1
p0 P= 1 P= 0.59 P= 0.088 P= 0.59 P= 0.088
active_met_875=1 0.83 (0.78-0.88) 0.86 (0.8-0.92) 0.86 (0.73-1.01) 1.03 (0.97-1.09) 1.03 (0.88-1.2) 8782.3/12673 3302.6/4784.4 320/475.6
p1 P= 4.3e-09 P= 2e-05 P= 0.063 P= 0.33 P= 0.71
E param by G
active_met_875 0.83 (0.78-0.88) 0.88 (0.79-0.97) 1.11 (0.8-1.54)
p P= 4.3e-09 P= 0.013 P= 0.54

Locuszoom

Func Annot