active_met_875 GWIS findings| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Female (Ca=8677,Co=12005) | Male (Ca=7706,Co=11604) | |
| (1) | (2) | (3) | |
| chr15_33001734_T_A_dose | 1.038 (0.961, 1.115) | 1.074 (0.978, 1.170) | 0.979 (0.849, 1.110) |
| active_met_875Yes | 0.802*** (0.739, 0.866) | 0.836*** (0.754, 0.918) | 0.762*** (0.661, 0.863) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 1.000 (0.996, 1.003) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | ||
| chr15_33001734_T_A_dose:active_met_875Yes | 1.170*** (1.081, 1.259) | 1.123* (1.008, 1.238) | 1.248** (1.103, 1.392) |
| Constant | 0.587** (0.231, 0.942) | 0.530* (0.020, 1.040) | 0.707 (0.202, 1.212) |
| Observations | 39,992 | 20,682 | 19,310 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 5.594e-04 | |||
| LRtest p = 4.803e-02 | |||
| LRtest p = 2.654e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Cohort (Ca=10301,Co=18860) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_33001734_T_A_dose | 1.038 (0.961, 1.115) | 1.043 (0.958, 1.129) | 1.006 (0.820, 1.192) |
| active_met_8751 | 0.802*** (0.739, 0.866) | 0.837*** (0.766, 0.908) | 0.675*** (0.528, 0.822) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.022 (0.957, 1.088) | 1.014 (0.933, 1.094) |
| chr15_33001734_T_A_dose:active_met_8751 | 1.170*** (1.081, 1.259) | 1.147** (1.046, 1.248) | 1.239* (1.038, 1.440) |
| Constant | 0.587** (0.231, 0.942) | 1.008 (0.686, 1.330) | 0.425*** (-0.032, 0.882) |
| Observations | 39,992 | 29,161 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 5.594e-04 | |||
| LRtest p = 7.858e-03 | |||
| LRtest p = 3.746e-02 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Proximal (Ca=4370,Co=23609) | Distal (Ca=5625,Co=23609) | Rectal (Ca=4480,Co=23609) | |
| (1) | (2) | (3) | (4) | |
| chr15_33001734_T_A_dose | 1.038 (0.961, 1.115) | 0.978 (0.853, 1.103) | 1.040 (0.931, 1.148) | 1.073 (0.930, 1.215) |
| active_met_8751 | 0.802*** (0.739, 0.866) | 0.727*** (0.625, 0.829) | 0.782*** (0.691, 0.874) | 0.873* (0.758, 0.989) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.048 (0.970, 1.126) | 0.803*** (0.728, 0.877) | 1.337*** (1.260, 1.415) |
| chr15_33001734_T_A_dose:active_met_8751 | 1.170*** (1.081, 1.259) | 1.176* (1.032, 1.319) | 1.200** (1.074, 1.327) | 1.180* (1.022, 1.338) |
| Constant | 0.587** (0.231, 0.942) | 0.252*** (-0.307, 0.810) | 0.073*** (-0.431, 0.577) | 0.393*** (-0.158, 0.943) |
| Observations | 39,992 | 27,979 | 29,234 | 28,089 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 5.594e-04 | ||||
| LRtest p = 2.621e-02 | ||||
| LRtest p = 4.450e-03 | ||||
| LRtest p = 3.824e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Normal (Ca=5528,Co=8430) | Overweight (Ca=3672,Co=4735) | Obese (Ca=6902,Co=10154) | |
| (1) | (2) | (3) | (4) | |
| chr15_33001734_T_A_dose | 1.038 (0.961, 1.115) | 1.081 (0.937, 1.225) | 0.989 (0.843, 1.135) | 1.024 (0.902, 1.145) |
| active_met_8751 | 0.802*** (0.739, 0.866) | 0.804*** (0.691, 0.918) | 0.790*** (0.660, 0.921) | 0.856** (0.756, 0.956) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.004 (1.000, 1.008) | 1.004 (0.997, 1.010) | 1.000 (0.996, 1.004) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 0.965 (0.877, 1.053) | 1.169** (1.054, 1.284) | 0.976 (0.897, 1.055) |
| chr15_33001734_T_A_dose:active_met_8751 | 1.170*** (1.081, 1.259) | 1.162 (1.001, 1.323) | 1.310** (1.130, 1.490) | 1.135 (0.995, 1.274) |
| Constant | 0.587** (0.231, 0.942) | 0.419** (-0.143, 0.982) | 1.492 (0.519, 2.465) | 0.600 (-0.023, 1.222) |
| Observations | 39,992 | 13,958 | 8,407 | 17,056 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 5.594e-04 | ||||
| LRtest p = 6.788e-02 | ||||
| LRtest p = 3.235e-03 | ||||
| LRtest p = 7.550e-02 | ||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Female (Ca=7898,Co=11164) | Male (Ca=7131,Co=10765) | |
| (1) | (2) | (3) | |
| chr15_33001734_T_A_dose | 1.050 (0.968, 1.132) | 1.080 (0.978, 1.182) | 1.001 (0.863, 1.139) |
| active_met_8751 | 0.803*** (0.736, 0.870) | 0.836*** (0.748, 0.923) | 0.768*** (0.661, 0.875) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 0.999 (0.996, 1.003) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | ||
| chr15_33001734_T_A_dose:active_met_8751 | 1.161** (1.067, 1.255) | 1.120 (0.999, 1.241) | 1.225** (1.073, 1.377) |
| Constant | 0.569** (0.208, 0.930) | 0.522* (0.005, 1.039) | 0.667 (0.152, 1.182) |
| Observations | 36,958 | 19,062 | 17,896 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.824e-03 | |||
| LRtest p = 6.687e-02 | |||
| LRtest p = 8.851e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Cohort (Ca=8947,Co=17180) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_33001734_T_A_dose | 1.050 (0.968, 1.132) | 1.059 (0.967, 1.151) | 1.006 (0.820, 1.192) |
| active_met_8751 | 0.803*** (0.736, 0.870) | 0.843*** (0.767, 0.920) | 0.675*** (0.528, 0.822) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.020 (0.953, 1.087) | 1.014 (0.933, 1.094) |
| chr15_33001734_T_A_dose:active_met_8751 | 1.161** (1.067, 1.255) | 1.134* (1.026, 1.242) | 1.239* (1.038, 1.440) |
| Constant | 0.569** (0.208, 0.930) | 0.993 (0.652, 1.335) | 0.425*** (-0.032, 0.882) |
| Observations | 36,958 | 26,127 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.824e-03 | |||
| LRtest p = 2.255e-02 | |||
| LRtest p = 3.746e-02 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Proximal (Ca=4367,Co=21929) | Distal (Ca=5625,Co=21929) | Rectal (Ca=4404,Co=21929) | |
| (1) | (2) | (3) | (4) | |
| chr15_33001734_T_A_dose | 1.050 (0.968, 1.132) | 0.986 (0.861, 1.111) | 1.048 (0.939, 1.157) | 1.087 (0.942, 1.232) |
| active_met_8751 | 0.803*** (0.736, 0.870) | 0.730*** (0.628, 0.832) | 0.787*** (0.695, 0.879) | 0.884* (0.767, 1.001) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.055 (0.977, 1.132) | 0.807*** (0.732, 0.881) | 1.349*** (1.270, 1.428) |
| chr15_33001734_T_A_dose:active_met_8751 | 1.161** (1.067, 1.255) | 1.168* (1.024, 1.311) | 1.192** (1.066, 1.319) | 1.160 (1.000, 1.320) |
| Constant | 0.569** (0.208, 0.930) | 0.251*** (-0.308, 0.809) | 0.072*** (-0.432, 0.576) | 0.393*** (-0.159, 0.945) |
| Observations | 36,958 | 26,296 | 27,554 | 26,333 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.824e-03 | ||||
| LRtest p = 3.354e-02 | ||||
| LRtest p = 6.291e-03 | ||||
| LRtest p = 6.779e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Normal (Ca=5027,Co=7768) | Overweight (Ca=3423,Co=4413) | Obese (Ca=6311,Co=9485) | |
| (1) | (2) | (3) | (4) | |
| chr15_33001734_T_A_dose | 1.050 (0.968, 1.132) | 1.085 (0.930, 1.240) | 0.998 (0.845, 1.152) | 1.046 (0.918, 1.175) |
| active_met_8751 | 0.803*** (0.736, 0.870) | 0.792*** (0.671, 0.914) | 0.795** (0.658, 0.932) | 0.869** (0.763, 0.974) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.003 (0.999, 1.007) | 1.004 (0.998, 1.011) | 1.001 (0.996, 1.005) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 0.953 (0.864, 1.042) | 1.191** (1.075, 1.308) | 0.970 (0.891, 1.050) |
| chr15_33001734_T_A_dose:active_met_8751 | 1.161** (1.067, 1.255) | 1.162 (0.990, 1.334) | 1.325** (1.137, 1.513) | 1.106 (0.959, 1.252) |
| Constant | 0.569** (0.208, 0.930) | 0.452** (-0.122, 1.025) | 1.495 (0.513, 2.478) | 0.526* (-0.105, 1.157) |
| Observations | 36,958 | 12,795 | 7,836 | 15,796 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.824e-03 | ||||
| LRtest p = 8.779e-02 | ||||
| LRtest p = 3.315e-03 | ||||
| LRtest p = 1.791e-01 | ||||
| TT | TA | AA | TA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| active_met_875=0 | 1 | 1.07 (0.97-1.17) | 0.98 (0.78-1.24) | 1.07 (0.97-1.17) | 0.98 (0.78-1.24) | 2558.4/3708.9 | 1280/1759.5 | 139.6/207.7 |
| p0 | P= 1 | P= 0.17 | P= 0.89 | P= 0.17 | P= 0.89 | |||
| active_met_875=1 | 0.81 (0.76-0.86) | 0.98 (0.91-1.05) | 1.19 (1.03-1.37) | 1.21 (1.15-1.28) | 1.47 (1.29-1.69) | 7884.9/12259.1 | 4021.2/5146.3 | 499/527.7 |
| p1 | P= 6.8e-11 | P= 0.57 | P= 0.019 | P= 1.3e-12 | P= 2e-08 | |||
| E param by G | ||||||||
| active_met_875 | 0.81 (0.76-0.86) | 0.92 (0.84-1.01) | 1.21 (0.93-1.57) | |||||
| p | P= 6.8e-11 | P= 0.064 | P= 0.16 | |||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Female (Ca=8677,Co=12005) | Male (Ca=7706,Co=11604) | |
| (1) | (2) | (3) | |
| chr15_32994756_C_T_dose_flipped | 1.000 (0.923, 1.076) | 1.040 (0.945, 1.135) | 0.934 (0.806, 1.063) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.825*** (0.743, 0.908) | 0.754*** (0.652, 0.856) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.006** (1.002, 1.009) | 1.000 (0.996, 1.003) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | ||
| chr15_32994756_C_T_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.152* (1.038, 1.265) | 1.267** (1.125, 1.410) |
| Constant | 0.597** (0.241, 0.952) | 0.537* (0.026, 1.047) | 0.722 (0.217, 1.227) |
| Observations | 39,992 | 20,682 | 19,310 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 9.272e-05 | |||
| LRtest p = 1.471e-02 | |||
| LRtest p = 1.092e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Cohort (Ca=10301,Co=18860) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32994756_C_T_dose_flipped | 1.000 (0.923, 1.076) | 1.012 (0.927, 1.096) | 0.932 (0.749, 1.115) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.832*** (0.760, 0.903) | 0.655*** (0.507, 0.803) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.022 (0.957, 1.088) | 1.013 (0.932, 1.093) |
| chr15_32994756_C_T_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.157** (1.057, 1.257) | 1.320** (1.123, 1.518) |
| Constant | 0.597** (0.241, 0.952) | 1.023 (0.701, 1.344) | 0.438*** (-0.019, 0.895) |
| Observations | 39,992 | 29,161 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 9.272e-05 | |||
| LRtest p = 4.286e-03 | |||
| LRtest p = 5.983e-03 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Proximal (Ca=4370,Co=23609) | Distal (Ca=5625,Co=23609) | Rectal (Ca=4480,Co=23609) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994756_C_T_dose_flipped | 1.000 (0.923, 1.076) | 0.923 (0.799, 1.047) | 1.028 (0.921, 1.135) | 1.057 (0.915, 1.198) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.710*** (0.608, 0.813) | 0.783*** (0.691, 0.875) | 0.874* (0.758, 0.991) |
| age_ref_imp | 1.003* (1.000, 1.005) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.048 (0.970, 1.125) | 0.802*** (0.727, 0.876) | 1.336*** (1.258, 1.414) |
| chr15_32994756_C_T_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.240** (1.098, 1.382) | 1.188** (1.063, 1.312) | 1.165 (1.009, 1.321) |
| Constant | 0.597** (0.241, 0.952) | 0.259*** (-0.300, 0.817) | 0.074*** (-0.430, 0.577) | 0.398** (-0.152, 0.949) |
| Observations | 39,992 | 27,979 | 29,234 | 28,089 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 9.272e-05 | ||||
| LRtest p = 2.749e-03 | ||||
| LRtest p = 6.538e-03 | ||||
| LRtest p = 5.394e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Normal (Ca=5528,Co=8430) | Overweight (Ca=3672,Co=4735) | Obese (Ca=6902,Co=10154) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994756_C_T_dose_flipped | 1.000 (0.923, 1.076) | 1.012 (0.870, 1.153) | 0.972 (0.829, 1.115) | 1.000 (0.878, 1.122) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.786*** (0.671, 0.900) | 0.798*** (0.666, 0.929) | 0.848** (0.748, 0.949) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.004 (1.000, 1.008) | 1.004 (0.997, 1.010) | 1.000 (0.996, 1.004) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 0.963 (0.875, 1.051) | 1.168** (1.053, 1.283) | 0.976 (0.897, 1.055) |
| chr15_32994756_C_T_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.223* (1.064, 1.381) | 1.265** (1.089, 1.442) | 1.151* (1.013, 1.290) |
| Constant | 0.597** (0.241, 0.952) | 0.431** (-0.132, 0.993) | 1.514 (0.541, 2.486) | 0.606 (-0.016, 1.229) |
| Observations | 39,992 | 13,958 | 8,407 | 17,056 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 9.272e-05 | ||||
| LRtest p = 1.280e-02 | ||||
| LRtest p = 8.896e-03 | ||||
| LRtest p = 4.636e-02 | ||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Female (Ca=7898,Co=11164) | Male (Ca=7131,Co=10765) | |
| (1) | (2) | (3) | |
| chr15_32994756_T_C_dose | 0.981 (0.900, 1.062) | 0.939 (0.838, 1.040) | 1.055 (0.919, 1.192) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.060 (0.854, 1.265) | 1.197 (0.941, 1.453) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 0.999 (0.996, 1.003) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | ||
| chr15_32994756_T_C_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.885* (0.766, 1.005) | 0.795** (0.645, 0.945) |
| Constant | 0.599** (0.217, 0.981) | 0.595 (0.055, 1.136) | 0.613 (0.057, 1.169) |
| Observations | 36,958 | 19,062 | 17,896 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 6.586e-04 | |||
| LRtest p = 4.624e-02 | |||
| LRtest p = 2.661e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Cohort (Ca=8947,Co=17180) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32994756_T_C_dose | 0.981 (0.900, 1.062) | 0.962 (0.871, 1.053) | 1.073 (0.890, 1.256) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.079 (0.897, 1.262) | 1.142 (0.804, 1.480) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.020 (0.953, 1.087) | 1.013 (0.932, 1.093) |
| chr15_32994756_T_C_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.883* (0.776, 0.990) | 0.757** (0.560, 0.955) |
| Constant | 0.599** (0.217, 0.981) | 1.083 (0.715, 1.451) | 0.381*** (-0.158, 0.919) |
| Observations | 36,958 | 26,127 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 6.586e-04 | |||
| LRtest p = 2.198e-02 | |||
| LRtest p = 5.983e-03 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Proximal (Ca=4367,Co=21929) | Distal (Ca=5625,Co=21929) | Rectal (Ca=4404,Co=21929) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994756_T_C_dose | 0.981 (0.900, 1.062) | 1.075 (0.951, 1.200) | 0.965 (0.858, 1.073) | 0.940 (0.795, 1.084) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.082 (0.837, 1.327) | 1.098 (0.885, 1.311) | 1.177 (0.906, 1.447) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.054 (0.976, 1.132) | 0.806*** (0.731, 0.880) | 1.348*** (1.269, 1.427) |
| chr15_32994756_T_C_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.812** (0.670, 0.954) | 0.847** (0.722, 0.972) | 0.866 (0.707, 1.025) |
| Constant | 0.599** (0.217, 0.981) | 0.223*** (-0.369, 0.814) | 0.078*** (-0.452, 0.609) | 0.452** (-0.141, 1.045) |
| Observations | 36,958 | 26,296 | 27,554 | 26,333 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 6.586e-04 | ||||
| LRtest p = 3.755e-03 | ||||
| LRtest p = 8.800e-03 | ||||
| LRtest p = 7.459e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Normal (Ca=5027,Co=7768) | Overweight (Ca=3423,Co=4413) | Obese (Ca=6311,Co=9485) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994756_T_C_dose | 0.981 (0.900, 1.062) | 0.969 (0.816, 1.122) | 1.007 (0.856, 1.157) | 0.976 (0.848, 1.104) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.133 (0.843, 1.423) | 1.288 (0.970, 1.606) | 1.086 (0.837, 1.335) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.003 (0.998, 1.007) | 1.004 (0.997, 1.011) | 1.001 (0.996, 1.005) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 0.951 (0.862, 1.040) | 1.190** (1.074, 1.307) | 0.971 (0.891, 1.050) |
| chr15_32994756_T_C_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.829* (0.659, 0.999) | 0.791* (0.607, 0.976) | 0.891 (0.745, 1.036) |
| Constant | 0.599** (0.217, 0.981) | 0.491* (-0.129, 1.110) | 1.490 (0.480, 2.501) | 0.558 (-0.103, 1.218) |
| Observations | 36,958 | 12,795 | 7,836 | 15,796 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 6.586e-04 | ||||
| LRtest p = 3.005e-02 | ||||
| LRtest p = 1.277e-02 | ||||
| LRtest p = 1.181e-01 | ||||
| CC | CT | TT | CT | TT | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| active_met_875=0 | 1 | 1.04 (0.94-1.14) | 0.89 (0.71-1.12) | 1.04 (0.94-1.14) | 0.89 (0.71-1.12) | 2532.4/3636.4 | 1303.7/1812 | 141.9/227.7 |
| p0 | P= 1 | P= 0.46 | P= 0.33 | P= 0.46 | P= 0.33 | |||
| active_met_875=1 | 0.8 (0.75-0.85) | 0.95 (0.89-1.02) | 1.13 (0.99-1.3) | 1.19 (1.13-1.26) | 1.42 (1.25-1.61) | 7689.9/11947.4 | 4161.8/5381.5 | 553.2/604 |
| p1 | P= 1.5e-11 | P= 0.19 | P= 0.076 | P= 1.1e-10 | P= 9.5e-08 | |||
| E param by G | ||||||||
| active_met_875 | 0.8 (0.75-0.85) | 0.92 (0.84-1.01) | 1.27 (0.98-1.64) | |||||
| p | P= 1.5e-11 | P= 0.067 | P= 0.069 | |||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Female (Ca=8677,Co=12005) | Male (Ca=7706,Co=11604) | |
| (1) | (2) | (3) | |
| chr15_32994777_T_C_dose_flipped | 1.000 (0.924, 1.077) | 1.040 (0.945, 1.135) | 0.936 (0.807, 1.065) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.825*** (0.742, 0.908) | 0.754*** (0.653, 0.856) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.006** (1.002, 1.009) | 1.000 (0.996, 1.003) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | ||
| chr15_32994777_T_C_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.153* (1.039, 1.266) | 1.266** (1.123, 1.408) |
| Constant | 0.597** (0.241, 0.952) | 0.537* (0.026, 1.047) | 0.722 (0.217, 1.226) |
| Observations | 39,992 | 20,682 | 19,310 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 9.265e-05 | |||
| LRtest p = 1.424e-02 | |||
| LRtest p = 1.159e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Cohort (Ca=10301,Co=18860) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32994777_T_C_dose_flipped | 1.000 (0.924, 1.077) | 1.012 (0.927, 1.096) | 0.935 (0.751, 1.118) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.831*** (0.760, 0.903) | 0.656*** (0.507, 0.804) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.022 (0.957, 1.088) | 1.013 (0.932, 1.094) |
| chr15_32994777_T_C_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.157** (1.058, 1.257) | 1.317** (1.119, 1.515) |
| Constant | 0.597** (0.241, 0.952) | 1.022 (0.701, 1.344) | 0.438*** (-0.020, 0.895) |
| Observations | 39,992 | 29,161 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 9.265e-05 | |||
| LRtest p = 4.096e-03 | |||
| LRtest p = 6.460e-03 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Proximal (Ca=4370,Co=23609) | Distal (Ca=5625,Co=23609) | Rectal (Ca=4480,Co=23609) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994777_T_C_dose_flipped | 1.000 (0.924, 1.077) | 0.923 (0.799, 1.047) | 1.030 (0.923, 1.137) | 1.057 (0.915, 1.198) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.710*** (0.608, 0.812) | 0.783*** (0.691, 0.876) | 0.874* (0.758, 0.991) |
| age_ref_imp | 1.003* (1.000, 1.005) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.048 (0.970, 1.125) | 0.802*** (0.727, 0.876) | 1.336*** (1.258, 1.414) |
| chr15_32994777_T_C_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.241** (1.099, 1.383) | 1.186** (1.062, 1.311) | 1.166 (1.010, 1.322) |
| Constant | 0.597** (0.241, 0.952) | 0.259*** (-0.300, 0.817) | 0.074*** (-0.430, 0.577) | 0.398** (-0.152, 0.949) |
| Observations | 39,992 | 27,979 | 29,234 | 28,089 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 9.265e-05 | ||||
| LRtest p = 2.681e-03 | ||||
| LRtest p = 6.960e-03 | ||||
| LRtest p = 5.256e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Normal (Ca=5528,Co=8430) | Overweight (Ca=3672,Co=4735) | Obese (Ca=6902,Co=10154) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994777_T_C_dose_flipped | 1.000 (0.924, 1.077) | 1.011 (0.869, 1.152) | 0.974 (0.831, 1.117) | 1.001 (0.879, 1.123) |
| active_met_875Yes | 0.794*** (0.730, 0.857) | 0.785*** (0.671, 0.900) | 0.798*** (0.667, 0.929) | 0.848** (0.748, 0.949) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.004 (1.000, 1.008) | 1.004 (0.997, 1.010) | 1.000 (0.996, 1.004) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 0.963 (0.875, 1.051) | 1.168** (1.053, 1.283) | 0.976 (0.897, 1.055) |
| chr15_32994777_T_C_dose_flipped:active_met_875Yes | 1.192*** (1.104, 1.279) | 1.224* (1.066, 1.383) | 1.264** (1.087, 1.440) | 1.151* (1.012, 1.290) |
| Constant | 0.597** (0.241, 0.952) | 0.431** (-0.131, 0.993) | 1.513 (0.540, 2.485) | 0.606 (-0.016, 1.229) |
| Observations | 39,992 | 13,958 | 8,407 | 17,056 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 9.265e-05 | ||||
| LRtest p = 1.226e-02 | ||||
| LRtest p = 9.324e-03 | ||||
| LRtest p = 4.642e-02 | ||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Female (Ca=7898,Co=11164) | Male (Ca=7131,Co=10765) | |
| (1) | (2) | (3) | |
| chr15_32994777_C_T_dose | 0.980 (0.899, 1.061) | 0.939 (0.838, 1.040) | 1.054 (0.918, 1.190) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.061 (0.855, 1.266) | 1.194 (0.938, 1.451) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 0.999 (0.996, 1.003) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | ||
| chr15_32994777_C_T_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.885* (0.765, 1.005) | 0.796** (0.646, 0.946) |
| Constant | 0.599** (0.217, 0.982) | 0.595 (0.054, 1.135) | 0.615 (0.059, 1.171) |
| Observations | 36,958 | 19,062 | 17,896 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 6.632e-04 | |||
| LRtest p = 4.511e-02 | |||
| LRtest p = 2.825e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Cohort (Ca=8947,Co=17180) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32994777_C_T_dose | 0.980 (0.899, 1.061) | 0.962 (0.872, 1.053) | 1.070 (0.887, 1.253) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.081 (0.898, 1.263) | 1.137 (0.800, 1.475) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.020 (0.953, 1.087) | 1.013 (0.932, 1.094) |
| chr15_32994777_C_T_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.882* (0.775, 0.989) | 0.759** (0.561, 0.957) |
| Constant | 0.599** (0.217, 0.982) | 1.083 (0.715, 1.451) | 0.382*** (-0.156, 0.921) |
| Observations | 36,958 | 26,127 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 6.632e-04 | |||
| LRtest p = 2.121e-02 | |||
| LRtest p = 6.460e-03 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Proximal (Ca=4367,Co=21929) | Distal (Ca=5625,Co=21929) | Rectal (Ca=4404,Co=21929) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994777_C_T_dose | 0.980 (0.899, 1.061) | 1.076 (0.951, 1.200) | 0.964 (0.857, 1.071) | 0.940 (0.795, 1.084) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.083 (0.838, 1.328) | 1.096 (0.883, 1.309) | 1.178 (0.908, 1.449) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.054 (0.976, 1.132) | 0.806*** (0.731, 0.880) | 1.348*** (1.269, 1.427) |
| chr15_32994777_C_T_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.811** (0.669, 0.953) | 0.848** (0.723, 0.973) | 0.865 (0.706, 1.024) |
| Constant | 0.599** (0.217, 0.982) | 0.222*** (-0.369, 0.814) | 0.079*** (-0.452, 0.609) | 0.452** (-0.141, 1.045) |
| Observations | 36,958 | 26,296 | 27,554 | 26,333 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 6.632e-04 | ||||
| LRtest p = 3.667e-03 | ||||
| LRtest p = 9.355e-03 | ||||
| LRtest p = 7.276e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Normal (Ca=5027,Co=7768) | Overweight (Ca=3423,Co=4413) | Obese (Ca=6311,Co=9485) | |
| (1) | (2) | (3) | (4) | |
| chr15_32994777_C_T_dose | 0.980 (0.899, 1.061) | 0.970 (0.817, 1.123) | 1.005 (0.855, 1.155) | 0.975 (0.847, 1.104) |
| active_met_8751 | 1.099 (0.941, 1.258) | 1.136 (0.845, 1.426) | 1.285 (0.967, 1.603) | 1.085 (0.837, 1.334) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.003 (0.998, 1.007) | 1.004 (0.997, 1.011) | 1.001 (0.996, 1.005) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 0.951 (0.862, 1.040) | 1.190** (1.074, 1.307) | 0.971 (0.891, 1.050) |
| chr15_32994777_C_T_dose:active_met_8751 | 0.851*** (0.759, 0.944) | 0.827* (0.657, 0.997) | 0.792* (0.608, 0.977) | 0.891 (0.745, 1.036) |
| Constant | 0.599** (0.217, 0.982) | 0.490* (-0.129, 1.109) | 1.495 (0.484, 2.505) | 0.558 (-0.103, 1.218) |
| Observations | 36,958 | 12,795 | 7,836 | 15,796 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 6.632e-04 | ||||
| LRtest p = 2.885e-02 | ||||
| LRtest p = 1.336e-02 | ||||
| LRtest p = 1.190e-01 | ||||
| TT | TC | CC | TC | CC | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| active_met_875=0 | 1 | 1.04 (0.94-1.14) | 0.89 (0.71-1.12) | 1.04 (0.94-1.14) | 0.89 (0.71-1.12) | 2531.6/3635.7 | 1304.5/1812.5 | 142/227.7 |
| p0 | P= 1 | P= 0.46 | P= 0.34 | P= 0.46 | P= 0.34 | |||
| active_met_875=1 | 0.8 (0.75-0.85) | 0.95 (0.89-1.02) | 1.13 (0.99-1.3) | 1.19 (1.13-1.26) | 1.42 (1.25-1.61) | 7688.3/11946.8 | 4163.4/5382 | 553.3/604.2 |
| p1 | P= 1.5e-11 | P= 0.19 | P= 0.075 | P= 9.3e-11 | P= 9.4e-08 | |||
| E param by G | ||||||||
| active_met_875 | 0.8 (0.75-0.85) | 0.92 (0.84-1.01) | 1.27 (0.98-1.64) | |||||
| p | P= 1.5e-11 | P= 0.067 | P= 0.07 | |||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Female (Ca=8677,Co=12005) | Male (Ca=7706,Co=11604) | |
| (1) | (2) | (3) | |
| chr15_32995298_C_A_dose | 1.012 (0.934, 1.090) | 1.038 (0.940, 1.135) | 0.971 (0.840, 1.103) |
| active_met_875Yes | 0.797*** (0.734, 0.860) | 0.827*** (0.745, 0.909) | 0.763*** (0.662, 0.864) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 1.000 (0.996, 1.003) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | ||
| chr15_32995298_C_A_dose:active_met_875Yes | 1.192*** (1.102, 1.282) | 1.157* (1.041, 1.273) | 1.248** (1.102, 1.393) |
| Constant | 0.592** (0.237, 0.947) | 0.536* (0.026, 1.046) | 0.709 (0.204, 1.213) |
| Observations | 39,992 | 20,682 | 19,310 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.275e-04 | |||
| LRtest p = 1.373e-02 | |||
| LRtest p = 2.882e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Cohort (Ca=10301,Co=18860) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32995298_C_A_dose | 1.012 (0.934, 1.090) | 1.017 (0.931, 1.104) | 0.977 (0.790, 1.164) |
| active_met_8751 | 0.797*** (0.734, 0.860) | 0.833*** (0.762, 0.903) | 0.668*** (0.521, 0.814) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.022 (0.957, 1.088) | 1.014 (0.933, 1.094) |
| chr15_32995298_C_A_dose:active_met_8751 | 1.192*** (1.102, 1.282) | 1.163** (1.061, 1.266) | 1.280* (1.078, 1.482) |
| Constant | 0.592** (0.237, 0.947) | 1.017 (0.695, 1.339) | 0.428*** (-0.028, 0.885) |
| Observations | 39,992 | 29,161 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.275e-04 | |||
| LRtest p = 3.728e-03 | |||
| LRtest p = 1.701e-02 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Proximal (Ca=4370,Co=23609) | Distal (Ca=5625,Co=23609) | Rectal (Ca=4480,Co=23609) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995298_C_A_dose | 1.012 (0.934, 1.090) | 0.946 (0.819, 1.072) | 1.036 (0.927, 1.145) | 1.062 (0.918, 1.207) |
| active_met_8751 | 0.797*** (0.734, 0.860) | 0.721*** (0.620, 0.822) | 0.783*** (0.692, 0.875) | 0.872* (0.757, 0.988) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.048 (0.971, 1.126) | 0.802*** (0.728, 0.877) | 1.337*** (1.259, 1.415) |
| chr15_32995298_C_A_dose:active_met_8751 | 1.192*** (1.102, 1.282) | 1.207* (1.062, 1.352) | 1.199** (1.072, 1.326) | 1.184* (1.024, 1.343) |
| Constant | 0.592** (0.237, 0.947) | 0.255*** (-0.303, 0.813) | 0.073*** (-0.431, 0.577) | 0.394*** (-0.156, 0.945) |
| Observations | 39,992 | 27,979 | 29,234 | 28,089 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.275e-04 | ||||
| LRtest p = 1.051e-02 | ||||
| LRtest p = 5.050e-03 | ||||
| LRtest p = 3.703e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Normal (Ca=5528,Co=8430) | Overweight (Ca=3672,Co=4735) | Obese (Ca=6902,Co=10154) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995298_C_A_dose | 1.012 (0.934, 1.090) | 1.031 (0.885, 1.177) | 0.956 (0.809, 1.103) | 1.014 (0.891, 1.138) |
| active_met_8751 | 0.797*** (0.734, 0.860) | 0.791*** (0.678, 0.904) | 0.789*** (0.659, 0.919) | 0.854** (0.754, 0.953) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.004 (1.000, 1.008) | 1.004 (0.997, 1.010) | 1.000 (0.996, 1.004) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 0.965 (0.877, 1.053) | 1.168** (1.053, 1.283) | 0.976 (0.897, 1.055) |
| chr15_32995298_C_A_dose:active_met_8751 | 1.192*** (1.102, 1.282) | 1.216* (1.053, 1.380) | 1.323** (1.142, 1.504) | 1.144 (1.003, 1.285) |
| Constant | 0.592** (0.237, 0.947) | 0.426** (-0.136, 0.989) | 1.511 (0.539, 2.483) | 0.602 (-0.020, 1.225) |
| Observations | 39,992 | 13,958 | 8,407 | 17,056 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.275e-04 | ||||
| LRtest p = 1.852e-02 | ||||
| LRtest p = 2.438e-03 | ||||
| LRtest p = 6.167e-02 | ||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Female (Ca=7898,Co=11164) | Male (Ca=7131,Co=10765) | |
| (1) | (2) | (3) | |
| chr15_32995298_C_A_dose | 1.032 (0.949, 1.114) | 1.054 (0.951, 1.157) | 0.998 (0.858, 1.137) |
| active_met_8751 | 0.800*** (0.733, 0.867) | 0.830*** (0.743, 0.917) | 0.769*** (0.663, 0.876) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 0.999 (0.996, 1.003) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | ||
| chr15_32995298_C_A_dose:active_met_8751 | 1.174*** (1.080, 1.269) | 1.141* (1.019, 1.263) | 1.222* (1.068, 1.376) |
| Constant | 0.572** (0.211, 0.933) | 0.526* (0.009, 1.043) | 0.667 (0.152, 1.182) |
| Observations | 36,958 | 19,062 | 17,896 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 8.777e-04 | |||
| LRtest p = 3.404e-02 | |||
| LRtest p = 1.033e-02 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Cohort (Ca=8947,Co=17180) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32995298_C_A_dose | 1.032 (0.949, 1.114) | 1.043 (0.951, 1.136) | 0.977 (0.790, 1.164) |
| active_met_8751 | 0.800*** (0.733, 0.867) | 0.842*** (0.766, 0.918) | 0.668*** (0.521, 0.814) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.020 (0.953, 1.087) | 1.014 (0.933, 1.094) |
| chr15_32995298_C_A_dose:active_met_8751 | 1.174*** (1.080, 1.269) | 1.138* (1.029, 1.248) | 1.280* (1.078, 1.482) |
| Constant | 0.572** (0.211, 0.933) | 0.998 (0.656, 1.339) | 0.428*** (-0.028, 0.885) |
| Observations | 36,958 | 26,127 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 8.777e-04 | |||
| LRtest p = 1.986e-02 | |||
| LRtest p = 1.701e-02 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Proximal (Ca=4367,Co=21929) | Distal (Ca=5625,Co=21929) | Rectal (Ca=4404,Co=21929) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995298_C_A_dose | 1.032 (0.949, 1.114) | 0.953 (0.826, 1.079) | 1.044 (0.934, 1.153) | 1.074 (0.927, 1.221) |
| active_met_8751 | 0.800*** (0.733, 0.867) | 0.724*** (0.622, 0.825) | 0.788*** (0.696, 0.879) | 0.882* (0.765, 0.999) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.055 (0.977, 1.132) | 0.807*** (0.732, 0.881) | 1.349*** (1.270, 1.428) |
| chr15_32995298_C_A_dose:active_met_8751 | 1.174*** (1.080, 1.269) | 1.199* (1.054, 1.344) | 1.191** (1.064, 1.319) | 1.167 (1.005, 1.330) |
| Constant | 0.572** (0.211, 0.933) | 0.254*** (-0.305, 0.812) | 0.072*** (-0.432, 0.576) | 0.395*** (-0.157, 0.946) |
| Observations | 36,958 | 26,296 | 27,554 | 26,333 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 8.777e-04 | ||||
| LRtest p = 1.356e-02 | ||||
| LRtest p = 6.926e-03 | ||||
| LRtest p = 5.954e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Normal (Ca=5027,Co=7768) | Overweight (Ca=3423,Co=4413) | Obese (Ca=6311,Co=9485) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995298_C_A_dose | 1.032 (0.949, 1.114) | 1.042 (0.885, 1.199) | 0.977 (0.823, 1.130) | 1.044 (0.914, 1.174) |
| active_met_8751 | 0.800*** (0.733, 0.867) | 0.781*** (0.660, 0.902) | 0.798** (0.661, 0.934) | 0.868** (0.763, 0.973) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.003 (0.999, 1.007) | 1.004 (0.997, 1.011) | 1.001 (0.996, 1.005) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 0.953 (0.864, 1.041) | 1.190** (1.074, 1.307) | 0.971 (0.891, 1.050) |
| chr15_32995298_C_A_dose:active_met_8751 | 1.174*** (1.080, 1.269) | 1.209* (1.035, 1.384) | 1.320** (1.131, 1.509) | 1.109 (0.961, 1.257) |
| Constant | 0.572** (0.211, 0.933) | 0.458** (-0.115, 1.031) | 1.507 (0.526, 2.489) | 0.527* (-0.104, 1.157) |
| Observations | 36,958 | 12,795 | 7,836 | 15,796 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 8.777e-04 | ||||
| LRtest p = 3.264e-02 | ||||
| LRtest p = 3.897e-03 | ||||
| LRtest p = 1.690e-01 | ||||
| CC | CA | AA | CA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| active_met_875=0 | 1 | 1.04 (0.94-1.14) | 0.95 (0.74-1.2) | 1.04 (0.94-1.14) | 0.95 (0.74-1.2) | 2602.3/3742.8 | 1244.6/1737.4 | 131.2/195.8 |
| p0 | P= 1 | P= 0.46 | P= 0.65 | P= 0.46 | P= 0.65 | |||
| active_met_875=1 | 0.8 (0.75-0.85) | 0.96 (0.9-1.04) | 1.17 (1.01-1.35) | 1.21 (1.14-1.27) | 1.46 (1.28-1.68) | 7930.5/12310.9 | 3985.9/5110 | 488.5/512.1 |
| p1 | P= 1.2e-11 | P= 0.33 | P= 0.033 | P= 1.1e-11 | P= 5.2e-08 | |||
| E param by G | ||||||||
| active_met_875 | 0.8 (0.75-0.85) | 0.93 (0.85-1.02) | 1.24 (0.94-1.62) | |||||
| p | P= 1.2e-11 | P= 0.13 | P= 0.12 | |||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Female (Ca=8677,Co=12005) | Male (Ca=7706,Co=11604) | |
| (1) | (2) | (3) | |
| chr15_32995764_C_G_dose | 1.014 (0.936, 1.093) | 1.041 (0.943, 1.138) | 0.972 (0.840, 1.103) |
| active_met_875Yes | 0.797*** (0.734, 0.861) | 0.828*** (0.746, 0.910) | 0.763*** (0.662, 0.864) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 1.000 (0.996, 1.003) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | ||
| chr15_32995764_C_G_dose:active_met_875Yes | 1.190*** (1.100, 1.280) | 1.154* (1.038, 1.270) | 1.248** (1.102, 1.394) |
| Constant | 0.592** (0.236, 0.947) | 0.536* (0.026, 1.046) | 0.708 (0.204, 1.213) |
| Observations | 39,992 | 20,682 | 19,310 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.476e-04 | |||
| LRtest p = 1.559e-02 | |||
| LRtest p = 2.876e-03 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Cohort (Ca=10301,Co=18860) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32995764_C_G_dose | 1.014 (0.936, 1.093) | 1.020 (0.933, 1.106) | 0.977 (0.790, 1.164) |
| active_met_8751 | 0.797*** (0.734, 0.861) | 0.834*** (0.763, 0.904) | 0.667*** (0.521, 0.814) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.022 (0.957, 1.088) | 1.014 (0.933, 1.094) |
| chr15_32995764_C_G_dose:active_met_8751 | 1.190*** (1.100, 1.280) | 1.160** (1.058, 1.263) | 1.282* (1.080, 1.484) |
| Constant | 0.592** (0.236, 0.947) | 1.016 (0.694, 1.338) | 0.429*** (-0.028, 0.885) |
| Observations | 39,992 | 29,161 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.476e-04 | |||
| LRtest p = 4.400e-03 | |||
| LRtest p = 1.622e-02 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Proximal (Ca=4370,Co=23609) | Distal (Ca=5625,Co=23609) | Rectal (Ca=4480,Co=23609) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995764_C_G_dose | 1.014 (0.936, 1.093) | 0.947 (0.821, 1.074) | 1.039 (0.930, 1.148) | 1.064 (0.920, 1.209) |
| active_met_8751 | 0.797*** (0.734, 0.861) | 0.721*** (0.620, 0.823) | 0.784*** (0.693, 0.876) | 0.873* (0.758, 0.988) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 1.048 (0.971, 1.126) | 0.802*** (0.728, 0.877) | 1.337*** (1.259, 1.415) |
| chr15_32995764_C_G_dose:active_met_8751 | 1.190*** (1.100, 1.280) | 1.206* (1.061, 1.351) | 1.196** (1.069, 1.323) | 1.183* (1.023, 1.342) |
| Constant | 0.592** (0.236, 0.947) | 0.255*** (-0.304, 0.813) | 0.073*** (-0.431, 0.577) | 0.394*** (-0.156, 0.944) |
| Observations | 39,992 | 27,979 | 29,234 | 28,089 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.476e-04 | ||||
| LRtest p = 1.081e-02 | ||||
| LRtest p = 5.704e-03 | ||||
| LRtest p = 3.781e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=16383,Co=23609) | Normal (Ca=5528,Co=8430) | Overweight (Ca=3672,Co=4735) | Obese (Ca=6902,Co=10154) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995764_C_G_dose | 1.014 (0.936, 1.093) | 1.038 (0.892, 1.184) | 0.955 (0.808, 1.102) | 1.015 (0.892, 1.139) |
| active_met_8751 | 0.797*** (0.734, 0.861) | 0.793*** (0.681, 0.906) | 0.788*** (0.657, 0.918) | 0.854** (0.754, 0.954) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.004 (1.000, 1.008) | 1.004 (0.997, 1.010) | 1.000 (0.996, 1.004) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | 0.965 (0.877, 1.053) | 1.168** (1.053, 1.283) | 0.976 (0.897, 1.055) |
| chr15_32995764_C_G_dose:active_met_8751 | 1.190*** (1.100, 1.280) | 1.207* (1.043, 1.370) | 1.329** (1.148, 1.511) | 1.143 (1.002, 1.284) |
| Constant | 0.592** (0.236, 0.947) | 0.425** (-0.137, 0.987) | 1.511 (0.539, 2.483) | 0.602 (-0.021, 1.224) |
| Observations | 39,992 | 13,958 | 8,407 | 17,056 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.476e-04 | ||||
| LRtest p = 2.417e-02 | ||||
| LRtest p = 2.048e-03 | ||||
| LRtest p = 6.301e-02 | ||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Female (Ca=7898,Co=11164) | Male (Ca=7131,Co=10765) | |
| (1) | (2) | (3) | |
| chr15_32995764_C_G_dose | 1.034 (0.951, 1.117) | 1.058 (0.955, 1.161) | 0.998 (0.859, 1.137) |
| active_met_8751 | 0.801*** (0.734, 0.868) | 0.831*** (0.744, 0.918) | 0.769*** (0.663, 0.876) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.006** (1.002, 1.010) | 0.999 (0.996, 1.003) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | ||
| chr15_32995764_C_G_dose:active_met_8751 | 1.172** (1.077, 1.267) | 1.138* (1.015, 1.260) | 1.222* (1.069, 1.376) |
| Constant | 0.571** (0.210, 0.932) | 0.525* (0.008, 1.043) | 0.666 (0.151, 1.181) |
| Observations | 36,958 | 19,062 | 17,896 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.009e-03 | |||
| LRtest p = 3.866e-02 | |||
| LRtest p = 1.022e-02 | |||
| Dependent variable: | |||
| outcome | |||
| All (Ca=15029,Co=21929) | Cohort (Ca=8947,Co=17180) | Case-Control (Ca=6082,Co=4749) | |
| (1) | (2) | (3) | |
| chr15_32995764_C_G_dose | 1.034 (0.951, 1.117) | 1.046 (0.954, 1.139) | 0.977 (0.790, 1.164) |
| active_met_8751 | 0.801*** (0.734, 0.868) | 0.843*** (0.767, 0.919) | 0.667*** (0.521, 0.814) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.002 (0.998, 1.006) | 1.004* (1.000, 1.008) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.020 (0.953, 1.087) | 1.014 (0.933, 1.094) |
| chr15_32995764_C_G_dose:active_met_8751 | 1.172** (1.077, 1.267) | 1.135* (1.026, 1.244) | 1.282* (1.080, 1.484) |
| Constant | 0.571** (0.210, 0.932) | 0.996 (0.655, 1.338) | 0.429*** (-0.028, 0.885) |
| Observations | 36,958 | 26,127 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.009e-03 | |||
| LRtest p = 2.305e-02 | |||
| LRtest p = 1.622e-02 | |||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Proximal (Ca=4367,Co=21929) | Distal (Ca=5625,Co=21929) | Rectal (Ca=4404,Co=21929) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995764_C_G_dose | 1.034 (0.951, 1.117) | 0.955 (0.828, 1.081) | 1.046 (0.937, 1.156) | 1.076 (0.929, 1.223) |
| active_met_8751 | 0.801*** (0.734, 0.868) | 0.724*** (0.622, 0.826) | 0.789*** (0.697, 0.880) | 0.882* (0.765, 0.999) |
| age_ref_imp | 1.003* (1.000, 1.006) | 0.998 (0.994, 1.002) | 1.022*** (1.019, 1.026) | 0.986*** (0.982, 0.990) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 1.055 (0.977, 1.132) | 0.807*** (0.732, 0.881) | 1.349*** (1.270, 1.427) |
| chr15_32995764_C_G_dose:active_met_8751 | 1.172** (1.077, 1.267) | 1.198* (1.053, 1.344) | 1.188** (1.061, 1.316) | 1.167 (1.005, 1.329) |
| Constant | 0.571** (0.210, 0.932) | 0.253*** (-0.305, 0.812) | 0.072*** (-0.432, 0.576) | 0.394*** (-0.157, 0.946) |
| Observations | 36,958 | 26,296 | 27,554 | 26,333 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.009e-03 | ||||
| LRtest p = 1.392e-02 | ||||
| LRtest p = 7.796e-03 | ||||
| LRtest p = 6.065e-02 | ||||
| Dependent variable: | ||||
| outcome | ||||
| All (Ca=15029,Co=21929) | Normal (Ca=5027,Co=7768) | Overweight (Ca=3423,Co=4413) | Obese (Ca=6311,Co=9485) | |
| (1) | (2) | (3) | (4) | |
| chr15_32995764_C_G_dose | 1.034 (0.951, 1.117) | 1.050 (0.893, 1.207) | 0.976 (0.822, 1.130) | 1.045 (0.915, 1.175) |
| active_met_8751 | 0.801*** (0.734, 0.868) | 0.783*** (0.662, 0.905) | 0.796** (0.660, 0.933) | 0.868** (0.763, 0.973) |
| age_ref_imp | 1.003* (1.000, 1.006) | 1.003 (0.999, 1.007) | 1.004 (0.997, 1.011) | 1.001 (0.996, 1.005) |
| energytot_imp | 1.000*** (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.025 (0.973, 1.076) | 0.953 (0.864, 1.041) | 1.190** (1.074, 1.307) | 0.971 (0.891, 1.050) |
| chr15_32995764_C_G_dose:active_met_8751 | 1.172** (1.077, 1.267) | 1.199* (1.024, 1.373) | 1.327** (1.138, 1.516) | 1.108 (0.961, 1.256) |
| Constant | 0.571** (0.210, 0.932) | 0.456** (-0.117, 1.029) | 1.507 (0.525, 2.489) | 0.526* (-0.105, 1.157) |
| Observations | 36,958 | 12,795 | 7,836 | 15,796 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.009e-03 | ||||
| LRtest p = 4.206e-02 | ||||
| LRtest p = 3.336e-03 | ||||
| LRtest p = 1.718e-01 | ||||
| CC | CG | GG | CG | GG | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| active_met_875=0 | 1 | 1.04 (0.94-1.14) | 0.95 (0.75-1.21) | 1.04 (0.94-1.14) | 0.95 (0.75-1.21) | 2601.7/3744.7 | 1245.1/1736.3 | 131.2/195 |
| p0 | P= 1 | P= 0.44 | P= 0.68 | P= 0.44 | P= 0.68 | |||
| active_met_875=1 | 0.8 (0.75-0.85) | 0.97 (0.9-1.04) | 1.18 (1.02-1.36) | 1.2 (1.14-1.27) | 1.47 (1.28-1.69) | 7932.2/12314.4 | 3984/5107.6 | 488.9/510.9 |
| p1 | P= 1.4e-11 | P= 0.33 | P= 0.028 | P= 1.3e-11 | P= 3.7e-08 | |||
| E param by G | ||||||||
| active_met_875 | 0.8 (0.75-0.85) | 0.93 (0.85-1.02) | 1.24 (0.94-1.62) | |||||
| p | P= 1.4e-11 | P= 0.12 | P= 0.12 | |||||
| Dependent variable: | |||
| outcome | |||
| All (Ca=16383,Co=23609) | Female (Ca=8677,Co=12005) | Male (Ca=7706,Co=11604) | |
| (1) | (2) | (3) | |
| chr13_61572969_G_A_dose | 0.943 (0.857, 1.029) | 0.919 (0.814, 1.024) | 0.995 (0.845, 1.144) |
| active_met_875Yes | 0.829*** (0.768, 0.889) | 0.844*** (0.765, 0.923) | 0.820*** (0.723, 0.917) |
| age_ref_imp | 1.003* (1.000, 1.005) | 1.006** (1.002, 1.009) | 1.000 (0.996, 1.003) |
| energytot_imp | 1.000** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.028 (0.977, 1.079) | ||
| chr13_61572969_G_A_dose:active_met_875Yes | 1.086 (0.988, 1.184) | 1.114 (0.989, 1.239) | 1.029 (0.865, 1.193) |
| Constant | 0.613** (0.258, 0.968) | 0.568* (0.058, 1.077) | 0.708 (0.204, 1.212) |
| Observations | 39,992 | 20,682 | 19,310 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 9.963e-02 | |||
| LRtest p = 8.979e-02 | |||
| LRtest p = 7.311e-01 | |||
| Dependent variable: | |||
| exposure_num | |||
| All (Ca=,Co=) | Cohort (Ca=,Co=) | Case-Control (Ca=,Co=) | |
| (1) | (2) | (3) | |
| chr13_61572969_G_A_dose | 1.022*** (1.014, 1.029) | 1.025*** (1.016, 1.034) | 1.013* (1.001, 1.025) |
| age_ref_imp | 1.000 (0.999, 1.000) | 1.000 (1.000, 1.001) | 0.999*** (0.998, 1.000) |
| energytot_imp | 1.000* (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | 1.069*** (1.057, 1.081) | 0.982** (0.970, 0.995) |
| Constant | 4.616*** (4.548, 4.685) | 5.218*** (5.155, 5.281) | 4.952*** (4.883, 5.020) |
| Observations | 39,992 | 29,161 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 3.179e-08 | |||
| LRtest p = 3.211e-07 | |||
| LRtest p = 3.721e-02 | |||
| Dependent variable: | ||||
| exposure_num | ||||
| All (Ca=,Co=) | Proximal (Ca=,Co=) | Distal (Ca=,Co=) | Rectal (Ca=,Co=) | |
| (1) | (2) | (3) | (4) | |
| chr13_61572969_G_A_dose | 1.022*** (1.014, 1.029) | 1.020*** (1.011, 1.029) | 1.019*** (1.010, 1.028) | 1.018*** (1.009, 1.027) |
| age_ref_imp | 1.000 (0.999, 1.000) | 1.000 (0.999, 1.001) | 1.000 (0.999, 1.000) | 1.000 (0.999, 1.000) |
| energytot_imp | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | 1.049*** (1.038, 1.060) | 1.051*** (1.040, 1.061) | 1.048*** (1.037, 1.058) |
| Constant | 4.616*** (4.548, 4.685) | 4.706*** (4.622, 4.789) | 4.726*** (4.645, 4.807) | 4.902*** (4.821, 4.983) |
| Observations | 39,992 | 27,979 | 29,234 | 28,089 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 3.179e-08 | ||||
| LRtest p = 2.678e-05 | ||||
| LRtest p = 3.537e-05 | ||||
| LRtest p = 9.689e-05 | ||||
| Dependent variable: | ||||
| exposure_num | ||||
| All (Ca=,Co=) | Normal (Ca=,Co=) | Overweight (Ca=,Co=) | Obese (Ca=,Co=) | |
| (1) | (2) | (3) | (4) | |
| chr13_61572969_G_A_dose | 1.022*** (1.014, 1.029) | 1.018** (1.006, 1.031) | 1.022* (1.004, 1.040) | 1.024*** (1.012, 1.035) |
| age_ref_imp | 1.000 (0.999, 1.000) | 1.000 (0.999, 1.000) | 1.001 (1.000, 1.002) | 1.000 (0.999, 1.001) |
| energytot_imp | 1.000* (1.000, 1.000) | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | 1.014 (0.999, 1.028) | 1.081*** (1.059, 1.103) | 1.053*** (1.039, 1.066) |
| Constant | 4.616*** (4.548, 4.685) | 5.013*** (4.913, 5.113) | 2.731*** (2.536, 2.926) | 5.064*** (4.948, 5.180) |
| Observations | 39,992 | 13,958 | 8,407 | 17,056 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 3.179e-08 | ||||
| LRtest p = 3.378e-03 | ||||
| LRtest p = 1.539e-02 | ||||
| LRtest p = 6.899e-05 | ||||
| Dependent variable: | |||
| exposure_num | |||
| All (Ca=,Co=) | Female (Ca=,Co=) | Male (Ca=,Co=) | |
| (1) | (2) | (3) | |
| chr13_61572969_G_A_dose | 1.021*** (1.014, 1.029) | 1.027*** (1.016, 1.039) | 1.016** (1.005, 1.026) |
| age_ref_imp | 1.000 (0.999, 1.000) | 0.999* (0.998, 1.000) | 1.000 (0.999, 1.001) |
| energytot_imp | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | ||
| Constant | 4.706*** (4.638, 4.775) | 4.848*** (4.744, 4.952) | 4.725*** (4.635, 4.815) |
| Observations | 36,958 | 19,062 | 17,896 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.147e-07 | |||
| LRtest p = 4.003e-06 | |||
| LRtest p = 3.672e-03 | |||
| Dependent variable: | |||
| exposure_num | |||
| All (Ca=,Co=) | Cohort (Ca=,Co=) | Case-Control (Ca=,Co=) | |
| (1) | (2) | (3) | |
| chr13_61572969_G_A_dose | 1.021*** (1.014, 1.029) | 1.025*** (1.015, 1.035) | 1.013* (1.001, 1.025) |
| age_ref_imp | 1.000 (0.999, 1.000) | 1.000 (0.999, 1.001) | 0.999*** (0.998, 1.000) |
| energytot_imp | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000* (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | 1.070*** (1.058, 1.082) | 0.982** (0.970, 0.995) |
| Constant | 4.706*** (4.638, 4.775) | 5.365*** (5.299, 5.431) | 4.952*** (4.883, 5.020) |
| Observations | 36,958 | 26,127 | 10,831 |
| Note: | p<0.05; p<0.01; p<0.001 | ||
| (PC and Study estimates omitted from table) | |||
| LRtest p = 1.147e-07 | |||
| LRtest p = 1.104e-06 | |||
| LRtest p = 3.721e-02 | |||
| Dependent variable: | ||||
| exposure_num | ||||
| All (Ca=,Co=) | Proximal (Ca=,Co=) | Distal (Ca=,Co=) | Rectal (Ca=,Co=) | |
| (1) | (2) | (3) | (4) | |
| chr13_61572969_G_A_dose | 1.021*** (1.014, 1.029) | 1.020*** (1.011, 1.029) | 1.020*** (1.010, 1.029) | 1.018*** (1.009, 1.027) |
| age_ref_imp | 1.000 (0.999, 1.000) | 1.000 (0.999, 1.001) | 0.999 (0.999, 1.000) | 1.000 (0.999, 1.000) |
| energytot_imp | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | 1.050*** (1.039, 1.060) | 1.051*** (1.040, 1.062) | 1.048*** (1.037, 1.059) |
| Constant | 4.706*** (4.638, 4.775) | 4.792*** (4.709, 4.876) | 4.814*** (4.732, 4.896) | 4.991*** (4.910, 5.072) |
| Observations | 36,958 | 26,296 | 27,554 | 26,333 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.147e-07 | ||||
| LRtest p = 3.521e-05 | ||||
| LRtest p = 3.878e-05 | ||||
| LRtest p = 1.193e-04 | ||||
| Dependent variable: | ||||
| exposure_num | ||||
| All (Ca=,Co=) | Normal (Ca=,Co=) | Overweight (Ca=,Co=) | Obese (Ca=,Co=) | |
| (1) | (2) | (3) | (4) | |
| chr13_61572969_G_A_dose | 1.021*** (1.014, 1.029) | 1.022*** (1.009, 1.034) | 1.026** (1.007, 1.044) | 1.018** (1.007, 1.030) |
| age_ref_imp | 1.000 (0.999, 1.000) | 0.999 (0.999, 1.000) | 1.001 (0.999, 1.002) | 1.000 (0.999, 1.000) |
| energytot_imp | 1.000 (1.000, 1.000) | 1.000*** (1.000, 1.000) | 1.000 (1.000, 1.000) | 1.000 (1.000, 1.000) |
| sex | 1.039*** (1.030, 1.048) | 1.012 (0.997, 1.027) | 1.082*** (1.060, 1.103) | 1.053*** (1.039, 1.067) |
| Constant | 4.706*** (4.638, 4.775) | 5.131*** (5.031, 5.231) | 2.811*** (2.616, 3.006) | 5.119*** (5.003, 5.236) |
| Observations | 36,958 | 12,795 | 7,836 | 15,796 |
| Note: | p<0.05; p<0.01; p<0.001 | |||
| (PC and Study estimates omitted from table) | ||||
| LRtest p = 1.147e-07 | ||||
| LRtest p = 7.993e-04 | ||||
| LRtest p = 6.296e-03 | ||||
| LRtest p = 2.515e-03 | ||||
| GG | GA | AA | GA | AA | N0 | N1 | N2 | |
|---|---|---|---|---|---|---|---|---|
| active_met_875=0 | 1 | 0.97 (0.88-1.08) | 0.77 (0.58-1.04) | 0.97 (0.88-1.08) | 0.77 (0.58-1.04) | 2947.7/4130.3 | 949.1/1402.6 | 81.2/143.1 |
| p0 | P= 1 | P= 0.59 | P= 0.088 | P= 0.59 | P= 0.088 | |||
| active_met_875=1 | 0.83 (0.78-0.88) | 0.86 (0.8-0.92) | 0.86 (0.73-1.01) | 1.03 (0.97-1.09) | 1.03 (0.88-1.2) | 8782.3/12673 | 3302.6/4784.4 | 320/475.6 |
| p1 | P= 4.3e-09 | P= 2e-05 | P= 0.063 | P= 0.33 | P= 0.71 | |||
| E param by G | ||||||||
| active_met_875 | 0.83 (0.78-0.88) | 0.88 (0.79-0.97) | 1.11 (0.8-1.54) | |||||
| p | P= 4.3e-09 | P= 0.013 | P= 0.54 | |||||